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UnknownPancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization.
Not available
S-EPMC2958310 | biostudies-literature
ProteomicsPax6os1 pull-down in MIN6 cell lysate
Pull-down experiment to identify protein binding partners of the lncRNA Pax6os1 in mouse insulinoma cell line MIN6 using in-vitro transcribed RNA.
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD052133 | Pride
Mouse lncrna silac 
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
UnknownGlucose regulates free cytosolic Zn²⁺ concentration, Slc39 (ZiP), and metallothionein gene expression in primary pancreatic islet β-cells.
Not available
S-EPMC3138249 | biostudies-literature
TranscriptomicsTranscription profiling by high throughput sequencing of pancreatic islets from R299Q AMPK gamma 2 knock-in mice
RNA-Seq to investigate significant transcriptional differences underlying the defective glucose-stimulated insulin secretion of R299Q AMPK g2 knock-in mice compared to wild-type littermate controls.
ORGANISM(S): Mus musculus 
2016-05-20 | E-MTAB-3938 | biostudies-arrayexpress
UnknownBinding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in vivo of a novel GLP-1R/GIPR dual agonist, HISHS-2001.
Not available
S-EPMC12409219 | biostudies-literature
UnknownAn alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes.
Not available
S-EPMC3210366 | biostudies-literature
MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
UnknownTranscription factor-7-like 2 (<i>TCF7L2</i>) gene acts downstream of the <i>Lkb1</i>/<i>Stk11</i> kinase to control mTOR signaling, β cell growth, and insulin secretion.
Not available
S-EPMC6130960 | biostudies-literature
UnknownAdipocyte-specific deletion of Tcf7l2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice.
Not available
S-EPMC7567653 | biostudies-literature
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