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ProteomicsPhosphate Starvation Signaling Increases Mitochondrial Membrane Potential through Respiration-independent Mechanisms
The mitochondrial membrane potential directly powers many critical functions of mitochondria, including ATP production, mitochondrial protein import, and metabolite transport. Its loss is a cardinal feature of aging and mitochondrial diseases, and cells closely monitor membrane potential as an indic...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-02-15 | PXD037405 | Pride
Mitochondria Phosphate 
ProteomicsThe biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder
We identified that peroxins were still expressed in Zellweger Spectrum Disorder (ZSD) and a subset of them accumulated on the mitochondrial membrane, which resulted in gross mitochondrial abnormalities and impaired mitochondrial metabolic function. In this complexome analysis we detected several per...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-06-25 | PXD024625 | Pride
Peroxisomes Mitocondrial quality control Mitochondria Peroxisomal biogenesis disorder Peroxisomal import Lc-msms Complexome profiling 
UnknownThe biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder
Not available
S-SCDT-EMBOR-2020-51991-T | biostudies-other
MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
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