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MetabolomicsSphingosine-1-phosphate receptor 1 promotes ovarian cancer tumorsphere proliferation and metastasis
Despite extensive clinical endeavors to enhance high-grade serous ovarian cancer (HGSOC) detection and treatment, an alarming half of diagnosed women succumb annually to this disease. Significantly, nearly all HGSOC cases manifest ascites at diagnosis, a poor prognostic indicator. Malignant ascites ...
2026-03-04 | MTBLS13770 | MetaboLights
MetabolomicsA homeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism

Cellular senescence affects many physiological and pathological processes and is characterized by durable cell cycle arrest, an inflammatory secretory phenotype and metabolic reprogramming. Here, by using dynamic transcriptome and metabolome profiling in human fibroblasts with different subtypes ...

2024-01-09 | MTBLS7118 | MetaboLights
MetabolomicsPhosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans
Metabolic stress due to nutrient excess and lipid accumulation is at the root of many age-associated disorders and the identification of therapeutic targets that mimic the beneficial effects of calorie restriction has clinical importance. Here, using C. elegans as a model organism, we study the role...
2021-09-28 | MTBLS3485 | MetaboLights
MetabolomicsRhizosphere reprogramming by phosphate slag enhances glutathione-centered redox regulation and root development in tobacco

Background and aims: Phosphate slag, a by-product of phosphorus and steel production, is a potential soil amendment that improves nutrient availability and redox stability. However, how it reshapes the rhizosphere microbiome and metabolism to promote tobacco (Nicotiana tabacum L.) root developmen...

2026-01-16 | MTBLS13273 | MetaboLights
MetabolomicsGlycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans
Metabolic stress caused by excess nutrients accelerates aging. We recently demonstrated that the newly discovered enzyme glycerol-3-phosphate phosphatase (G3PP; gene Pgp), which operates an evolutionarily conserved glycerol shunt that hydrolyzes glucose-derived glycerol-3-phosphate to glycerol, coun...
2024-02-07 | MTBLS6847 | MetaboLights
MetabolomicsMetabolome of aluminum-tolerant phosphate-solubilizing fungi

We constructed a bacterial fungal synthetic community and found that it has stronger phosphorus solubilization ability than a single bacterium or fungus. Among them, fungi mainly play a role in phosphorus solubilization, while bacteria can promote fungal phosphorus solubilization. Through metabol...

2026-03-09 | MTBLS14003 | MetaboLights
MetabolomicsA Phosphate starvation response gene (psr1-like) is present in Micromonas pusilla and other marine algae and coordinates the metabolic response to phosphate deficiency
Both marine phytoplankton and terrestrial plants have to deal with limited bioavailability of the key life nutrient, phosphate. In freshwater algae and plants, a phosphate starvation response gene (psr1) has been characterized, which encodes for a transcription factor that regulates the metabolic re...
2016-02-01 | MTBLS295 | MetaboLights
MetabolomicsMetabolomic data related to the alleviation of cardiac ischemia/reperfusion injury by NADPH derived from pentose phosphate pathway

Exercise promotes physiological cardiomyocyte growth and protects against ischemia/reperfusion (I/R) injury in the heart. The molecular mechanism by which exercise benefits cardiac metabolism and function remains largely unknown. Exercise (swimming or treadmill)-induced physiological hypertrophy ...

2026-05-14 | MTBLS14272 | MetaboLights
MetabolomicsRoot exudate metabolomics of PpPEPC1b-overexpressing rice under phosphate deficiency
Untargeted LC-MS/MS metabolomics of root exudate collection solution from wild-type rice (Oryza sativa L. Zhonghua 11) and three independent overexpression lines (OE8, OE15, OE33) of the elephant grass (Pennisetum purpureum) phosphoenolpyruvate carboxylase gene PpPEPC1b, grown under low phosphate (5...
2026-08-20 | MTBLS15387 | MetaboLights
MetabolomicsNEFA Profile Response to Triphenyl Phosphate Exposure
Not available
ORGANISM(S): Rattus norvegicus 
ST000600 | MetabolomicsWorkbench
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