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MetabolomicsMulti-omics resources for targeted agronomic improvement of pigmented rice

Pigmented rice (Oryza sativa L.) is a rich source of nutrients, but pigmented lines typically have long life cycles and limited productivity. Here we generated genome assemblies of 5 pigmented rice varieties and evaluated the genetic variation among 51 pigmented rice varieties by reseque...

2023-03-27 | MTBLS3320 | MetaboLights
UnknownTBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer.
Not available
S-EPMC4451173 | biostudies-literature
TranscriptomicscaArray_harri-00137: Predictors of Resistance to Preoperative Trastuzumab and Vinorelbine for HER2-Positive Early Breast Cancer
To assess pathologic complete response (pCR), clinical response, feasibility, safety, and potential predictors of response to preoperative trastuzumab plus vinorelbine in patients with operable, human epidermal growth factor receptor 2 (HER2)-positive breast cancer. EXPERIMENTAL DESIGN: 48 patients ...
ORGANISM(S): Homo sapiens 
2015-06-25 | E-GEOD-70233 | biostudies-arrayexpress
MetabolomicsChanges in lipid profiles of epileptic mouse model

INTRODUCTION: Approximately 1% of the world's population is impacted by epilepsy, a chronic neurological disorder characterized by seizures. One-third of epileptic patients are resistant to AEDs, or have medically refractory epilepsy (MRE). One non-invasive treatment that exists...

2022-01-06 | MTBLS1432 | MetaboLights
UnknownPlasma metabolomics of children with aberrant serum lipids and inadequate micronutrient intake.
Not available
S-EPMC6209210 | biostudies-literature
UnknownSustained efficacy of incobotulinumtoxina repeated injections for upper-limb post-stroke spasticity: A post hoc analysis.
Not available
S-EPMC8772361 | biostudies-literature
GenomicsTissue-specific regulation of chromatin insulator function
Chromatin insulators organize the genome into distinct transcriptional domains and contribute to cell type-specific chromatin organization. However, factors regulating tissue-specific insulator function have not yet been discovered. Here we identify the RNA recognition motif-containing protein, Shep...
ORGANISM(S): Drosophila melanogaster 
2012-11-30 | E-GEOD-40797 | biostudies-arrayexpress
GenomicsRNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function
Chromatin insulators and Polycomb group (PcG) complexes control nuclear organization to effect changes in gene expression. In Drosophila, RNA silencing pathways influence long range interactions mediated by PcG proteins and nuclear localization of the gypsy insulator; however, the underlying mechan...
ORGANISM(S): Drosophila melanogaster 
2011-08-15 | E-GEOD-22623 | biostudies-arrayexpress
TranscriptomicsGenome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila
Chromatin insulators are functionally conserved DNA-protein complexes that are situated throughout the genome and organize independent transcriptional domains.  Previous work implicated RNA as an important cofactor in chromatin insulator activity, although the mechanisms by which RNA affects insulat...
ORGANISM(S): Drosophila melanogaster 
2013-01-29 | E-GEOD-41950 | biostudies-arrayexpress
UnknownIntracellular secretory leukoprotease inhibitor modulates inositol 1,4,5-triphosphate generation and exerts an anti-inflammatory effect on neutrophils of individuals with cystic fibrosis and chronic obstructive pulmonary disease.
Not available
S-EPMC3773400 | biostudies-literature
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