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TranscriptomicsMinor compensatory changes in SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats do not detract from their utility in the study of transporter-mediated pharmacokinetics.
Mdr1a-, Bcrp-, and Mrp2-knockout rats are a more practical species for ADME studies than murine models and previously demonstrated expected alterations in pharmacokinetics of various probe substrates. At present, gene expression and pathology changes were systematically studied in small intestine, ...
ORGANISM(S): Rattus norvegicus 
2013-04-08 | E-GEOD-44962 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver genomic responses to ciguatoxin (P-CTX-1)
Ciguatoxins (CTX) are polyether neurotoxins responsible for ciguatera, the most common fish-borne food poisoning in humans. This study characterizes the global transcriptional response of mouse liver to a symptomatic dose (0.26 ng/g) of the highly potent Pacific ciguatoxin-1 (P-CTX-1). At 1 h post...
ORGANISM(S): Mus musculus 
2008-06-20 | E-GEOD-10768 | biostudies-arrayexpress
GenomicsTotal RNA Pol2 ChIP-seq in mES cells treated with flavopiridol (Cdk9 inhibitor) after DSIF and NELF knockdown
Recent studies have found that promoter-proximal pausing occurs at most Pol2-regulated genes. DSIF and NELF function as negative elongation factors and promote Pol2 pausing. P-TEFb, whose enzymatic activity lies in the kinase Cdk9, positively regulates the transition into productive elongation by ...
ORGANISM(S): Mus musculus 
2011-01-19 | E-GEOD-26658 | biostudies-arrayexpress
UnknownRyan White HIV/AIDS Program Assistance and HIV Treatment Outcomes.
Not available
S-EPMC5087096 | biostudies-literature
UnknownIdentification of NAD(P)H quinone oxidoreductase activity in azoreductases from P. aeruginosa: azoreductases and NAD(P)H quinone oxidoreductases belong to the same FMN-dependent superfamily of enzymes.
Not available
S-EPMC4051601 | biostudies-literature
UnknownThe social network of medical case managers, housing providers, and health department staff in the Ryan White HIV/AIDS Program: A Midwest case study.
Not available
S-EPMC7454952 | biostudies-literature
UnknownInitiating Opioid Use Disorder Medication via Telemedicine During COVID-19: Implications for Proposed Reforms to the Ryan Haight Act.
Not available
S-EPMC8553288 | biostudies-literature
UnknownA hybrid type II effectiveness-implementation trial of a positive emotion regulation intervention among people living with HIV engaged in Ryan White Medical Case Management: protocol and design for the ORCHID study.
Not available
S-EPMC11428577 | biostudies-literature
ProteomicsEffect of LPS and the glucocorticoid dexamethasone on the mouse Bone Marrow Derived Macrophage Proteome
The concentrations and copy number of proteins in the mouse Bone Marrow Derived proteome was determined for control, 10 ng/mL LPS stimulation, and LPS stimulation plus the addition of 100 nM dexamethasone, after an incubation for 24 hours and with four biological replicates for each condition. Over ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD041375 | Pride
Innate immunity Glucocorticoid Macrophage Dexamethasone Mouse Type i interferon 
UnknownAcceptability, Feasibility, and Appropriateness of Implementation of Long-acting Injectable Antiretrovirals: A National Survey of Ryan White Clinics in the United States.
Not available
S-EPMC10386882 | biostudies-literature
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