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TranscriptomicsDNA methylation profiles (RRBS) of the muscle of pigs distinct in metabolic types and genetic background
DNA methylation is an epigenetic mechanism that plays roles in gene regulation and expression. This study aims to profile DNA methylation at genome-wide scale and single base resolution using reduced representation bisulfite sequencing (RRBS) of the muscle of pigs differing in muscle metabolism and ...
ORGANISM(S): Sus scrofa 
2024-12-01 | E-MTAB-7338 | biostudies-arrayexpress
ProteomicsHeart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2.
Cognitive dysfunction (CD) in heart failure (HF) adversely affects treatment compliance and quality of life. Although, ryanodine receptor type 2 (RyR2) has been linked to cardiac muscle dysfunction, its role in CD remains unclear. Here, we show in hippocampal neurons from patients and mice with HF t...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-30 | PXD042295 | Pride
Calcium Cognitive dysfunction Heart failure Ryanodine receptor 
ModelsKeizer1996_Ryanodine_receptor_adaptation
The model reproduces the time profile of Open probability of the ryanodine receptor as shown in Fig 2A and 2B of the paper. The model was successfully tested on MathSBML and Jarnac. To the extent possible under law, all copyright and related or neighbouring rights to this en...
2024-09-02 | BIOMD0000000060 | BioModels
GenomicsEnhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling
Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling
PRJNA665524 | ENA
TranscriptomicsExpression in myocardial tissues of Great Dane dogs with cardiomyopathy
Oligonucleotide microarray analysis of left ventricular tissues from 3 Great dane dogs with dilated cardiomyopathy and 3 control dogs was performed. Three hundred and twenty three differentially expressed transcripts were detected. The transcript demonstrating the highest degree of upregulation wa...
ORGANISM(S): Canis lupus familiaris 
2010-04-09 | E-GEOD-16049 | biostudies-arrayexpress
GenomicsFoxP3-mediated blockage of ryanodine receptor 2 is the molecular basis for the contact-based suppression by regulatory T cells
FoxP3-mediated blockage of ryanodine receptor 2 is the molecular basis for the contact-based suppression by regulatory T cells
PRJNA993577 | ENA
UnknownThe ryanodine receptor is essential for larval development in Drosophila melanogaster.
Not available
S-EPMC18538 | biostudies-literature
ProteomicsPhosphorylation-dependent Interactome of Ryanodine Recep-tor Type-2 in the Heart
Background: Hyperphosphorylation of the calcium release channel/ryanodine receptor type 2 (RyR2) at serine 2814 (S2814) is associated with multiple cardiac diseases including atrial fibrilla-tion and heart failure. Despite recent advances, the molecular mechanisms driving pathological changes associ...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-07 | PXD026350 | Pride
Ryr2 Heart Phosphorylation Interactome 
UnknownAIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor.
Not available
S-EPMC5680226 | biostudies-literature
UnknownStructural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Not available
S-EPMC11402997 | biostudies-literature
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