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TranscriptomicsAbnormal Developmental Control of Replication Timing Domains in Pediatric Acute Lymphoblastic Leukemia
Abnormal replication timing has been observed in cancer but no study has comprehensively evaluated this misregulation. We generated genome-wide replication timing profiles for pediatric leukemias from 17 patients and 3 cell lines, as well as normal B and T cells. Non-leukemic EBV-transformed lymphob...
ORGANISM(S): Homo sapiens 
2012-05-16 | E-GEOD-37987 | biostudies-arrayexpress
TranscriptomicsReplication timing profiling by Repli-chip in Mus musculus
The replication timing program, or the order in which DNA is duplicated during S-phase, is associated with various features of chromosome structure and function, including gene expression, histone modifications, and 3-D compartmentalization of chromatin. 3 cell types, with a total of 6 individual re...
ORGANISM(S): Mus musculus 
2013-04-16 | E-GEOD-45716 | biostudies-arrayexpress
TranscriptomicsReplication Timing Reveal An Epigenetic Commitment To Differentiation Prior To Germ Layer Specification (WG_CGH, RT)
Differentiation of mouse embryonic stem cells (mESCs) is accompanied by global changes in replication timing. To elucidate this reorganization process and explore its potential impact on mouse development, we constructed genome-wide replication-timing profiles of 15 independent mouse cell types repr...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-17983 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Dynamics of Replication Timing Revealed by In Vitro Models of Mouse Embryogenesis (Expression)
Differentiation of mouse embryonic stem cells (mESCs) is accompanied by changes in replication timing. To explore the relationship between replication timing and cell fate transitions, we constructed genome-wide replication-timing profiles of 22 independent mouse cell lines representing 10 stages of...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-17980 | biostudies-arrayexpress
TranscriptomicsEvolutionarily conserved replication timing profiles distinguish cell types and predict long range chromatin interaction
Extensive changes in replication timing occur during early mouse development, but their biological significance remains uncertain. To identify evolutionarily conserved features of replication timing and their relationships to epigenetic properties in humans, we profiled replication timing genome-wid...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-20027 | biostudies-arrayexpress
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