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TranscriptomicsDeregulated Myc expression induces addiction to AMPK-related kinase 5
U2OS cells were infected with shRNA vector targeting Ark5 or control vector, selected on puromycin for 48hrs, seeded on 5cm dishes at 20% confluency and harvested in triplicate 48hrs later
ORGANISM(S): Homo sapiens 
2012-03-01 | E-MEXP-3543 | biostudies-arrayexpress
TranscriptomicsMYC-ER and MYC-ER V394D induced gene expression changes in MCF10A cells
Oncogenic levels of Myc expression sensitize cells to multiple apoptotic stimuli and this protects long-lived organisms from cancer development. How cells discriminate physiological from supra-physiological levels of Myc is largely unknown. Here we show that induction of apoptosis by Myc in breast e...
ORGANISM(S): Homo sapiens 
2015-07-10 | E-GEOD-59145 | biostudies-arrayexpress
GenomicsActivation and repression by oncogenic Myc shapes tumour-specific gene expression profiles
In mammalian cells, the Myc oncoprotein binds to thousands of promoters. During mitogenic stimulation of primary lymphocytes, Myc promotes an increase in expression of virtually all genes. In contrast, Myc-driven tumour cells differ from normal cells in expression of specific sets of up- and downreg...
ORGANISM(S): Homo sapiens 
2014-07-10 | E-GEOD-44672 | biostudies-arrayexpress
TranscriptomicsSmall noncoding RNAs in tomato pollen
We used tomato pollen in order to identify pollen stage-specific small non-coding RNAs (sncRNAs) and their target mRNAs. We further deployed elevated temperatures to discern stress responsive sncRNAs. For this purpose high throughput sncRNA-sequencing was performed for three-replicated sncRNAs libra...
ORGANISM(S): Solanum lycopersicum 
2015-08-20 | E-MTAB-3830 | biostudies-arrayexpress
TranscriptomicsNFATc1 cooperates with KrasG12D to promote pancreatic carcinogenesis.
Primary murine pancreatic cancer cells (referred to as NKC cells) derived from transgenic mice with pancreas-specific constitutive activation of NFATc1 and KrasG12D mutation in the presence or absence of NFATc1 expression were analyzed for target gene signatures.
ORGANISM(S): Mus musculus 
2014-06-30 | E-MTAB-1244 | biostudies-arrayexpress
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