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TranscriptomicsAltered gene expression in Werner & Bloom syndromes is associated with sequences having G-quadruplex forming potential
The human Werner and Bloom syndromes (WS and BS) are caused by deficiencies in the WRN and BLM RecQ helicases, respectively. WRN, BLM and their S. cerevisiae homologue Sgs1, are particularly active in vitro in unwinding G-quadruplex DNA (G4-DNA), a family of non-canonical nucleic acid structures fo...
ORGANISM(S): Homo sapiens 
2009-12-09 | E-GEOD-19205 | biostudies-arrayexpress
TranscriptomicsGenome-wide double-stranded RNA sequencing reveals the functional significance of base-paired RNAs in Arabidopsis
The functional structure of all biologically active molecules is dependent on intra- and inter-molecular interactions. This is especially evident for RNA molecules whose functionality, maturation, and regulation requires formation of correct secondary structure through encoded base-pairing interacti...
ORGANISM(S): Arabidopsis thaliana 
2010-10-04 | E-GEOD-23439 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of RNA secondary structure conservation between two metazoans
The secondary structure of RNA is necessary for its maturation, regulation, and processing. However, the global influence of RNA folding in eukaryotes is still unclear. Here, we identify evolutionarily conserved features of RNA secondary structure in metazoans by applying our high-throughput, sequen...
ORGANISM(S): Caenorhabditis elegans 
2012-01-26 | E-GEOD-29571 | biostudies-arrayexpress
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