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MetabolomicsGluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and H3K9me3 to suppress HCC progression
Deciphering the crosstalk between metabolic reprogramming and epigenetic regulation is a promising strategy for cancer therapy. In this study, we discovered that the gluconeogenic enzyme PCK1 fuels the generation of S-adenosylmethionine (SAM) through the serine synthesis pathway. The methyltransfera...
2025-08-09 | MTBLS7651 | MetaboLights
MetabolomicsRegional HNSCC metabolomics reveals widespread changes to one-carbon metabolism and S-adenosylmethionine metabolism across tumour core, tumour edge and adjacent non-tumour tissues

Cancer, including head and neck squamous cell carcinoma (HNSCC), induces changes to metabolism that drive the disease. Regional metabolomics can help to understand metabolic variation across the tumour including changes near the tumour core, where hypoxia is likely more pronounced. We apply ultra...

2026-06-03 | MTBLS1905 | MetaboLights
TranscriptomicsS-adenosylmethionine modifies cocaine-induced DNA methylation and increases locomotor sensitization in mice
The aim of the study was to investigate whether environmental factors like S-adenosylmethionine (SAM) via affecting epigenome could alter cocaine-induced gene expression and locomotor sensitization in mice. Using mouse nucleus accumbens (NAc) tissue, whole-genome gene expression profiling revealed t...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-48365 | biostudies-arrayexpress
TranscriptomicsS-Adenosylmethionine treatment diminishes the proliferation of castration- resistant prostate cancer cells by modulating the expression of miRNAs
AdoMet (S-adenosylmethionine) inhibits cancer cell proliferation and migration via epigenetic alterations. The aim of this study was to investigate whether AdoMet may cause alterations in miRNA expression profiles important for the initiation and progression of prostate cancer. PC-3 cells were treat...
ORGANISM(S): Homo sapiens 
2024-09-10 | E-MTAB-14388 | biostudies-arrayexpress
TranscriptomicsS-adenosylmethionine (SAM) changes DNA methylation patterns in prostate cancer cells
Genome-wide DNA methylation profiling of human PC3 invasive prostate cancer cell line treated with vehicle control (SAH, S-adenosylhomocysteine) and with SAM (S-adenosylmethionine) as well as of untreated human LNCaP non-invasive prostate cancer cell line. The Illumina Infinium 450k Human DNA Methyl...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-62053 | biostudies-arrayexpress
GenomicsDNA methylation status of myelinating Schwann cells during development and in diabetic neuropathy [Bisulfite-Seq2]
DNA methylation is a key epigenetic regulator of mammalian embryogenesis and somatic cell differentiation. Using high-resolution genome-scale maps of methylation patterns, we show that the formation of myelin in the peripheral nervous system, proceeds with progressive DNA demethylation, which coinci...
ORGANISM(S): Mus musculus 
2014-01-27 | E-GEOD-51031 | biostudies-arrayexpress
GenomicsTreatment of prostate cancer cells with S-adenosylmethionine leads to genomewide alterations of transcription profiles.
The analysis investigates the impact of methyl donor S-adenosylmethionin on transcription and methylation profiles of prostate carcinoma cells. PC-3 cells (Prostatecarcinoma cells) were treated with 160 micromolar S-adenosylmethionine or vehicle
ORGANISM(S): Homo sapiens 
2015-07-25 | E-GEOD-71303 | biostudies-arrayexpress
ProteomicsRIPK1 senses S-adenosylmethionine depletion to drive cell death and inflammation
We show that RIPK1, a key mediator of cell death and inflammation, senses the abundance of methionine and its metabolite, S-adenosylmethionine (SAM), to dictate cell survival and death.
ORGANISM(S): Homo Sapiens 
2024-12-19 | PXD059023 |
GenomicsFormaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism
Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism
PRJNA1012734 | ENA
Genomicss-Adenosylmethionine (SAM) diet defines offspring epigenetic modification and intergenerational immune response.
s-Adenosylmethionine (SAM) diet defines offspring epigenetic modification and intergenerational immune response.
PRJNA1090501 | ENA
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