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TranscriptomicsExpression data from wild type and deltaS4473 Shigella flexneri 2457T
Comparison of wild type S. flexneri 2457T gene expression to deletion mutant of S. flexneri 2457T gene S4473 at three growth phases and intracellularly Broth culture was grown to mid-log in LB, intracellular growth was 3 hours post invasion of HCT-8 cell (colonic epithelial cell line).
ORGANISM(S): Shigella flexneri 2a str. 2457T 
2013-10-18 | E-GEOD-40851 | biostudies-arrayexpress
TranscriptomicsDual-transcriptome of Shigella flexneri infecting human HCT116 cells
Analyse the transcriptionnal changes of human colon epithelial cells (HCT116) associated with Shigella flexneri (M90T) infection and correlated with the bacterial transcriptional program.
ORGANISM(S): Homo sapiens 
2024-12-01 | E-MTAB-14119 | biostudies-arrayexpress
TranscriptomicsIdentification of IFNg-regulated, IRF1-dependent genes in Shigella flexneri-infected mouse embryonic fibroblasts (MEFs)
This experiment was designed to identify IFNg-regulated, IRF1-dependent genes during infection with the intracellular pathogen Shigella flexneri. WT and Irf1-/- MEFs were stimulated for 18 hours with IFNg or left unstimulated; all of the cells were subsequently infected for 6 hours with S. flexneri...
ORGANISM(S): Mus musculus 
2011-09-01 | E-MTAB-713 | biostudies-arrayexpress
TranscriptomicsExpression analysis of Shigella flexneri 2a strain 301
Investigation of whole genome gene expression to identify overlooked sRNAs and sORFs. Background The completion of numerous genome sequences has introduced an era of whole-genome study. However, many real genes, including small RNAs (sRNAs) and small ORFs (sORFs), are missed in genome annotation. In...
ORGANISM(S): Shigella flexneri 2a str. 301 
2011-06-27 | E-GEOD-22800 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis of Shigella flexneri and Shigella sonnei Generalized Modules for Membrane Antigens (GMMA) reveals highly pure preparations.
Shigella flexneri 2a and Shigella sonnei were genetically modified to shed large quantities of outer membrane blebs. The blebs, called Generalized Modules for Membrane Antigens (GMMA), were purified and the protein content was estimated using the label-free iBAQ procedure. There were 2308 proteins i...
ORGANISM(S): Shigella flexneri 2a str. 2457T Shigella sonnei 53G 
2016-01-12 | PXD002517 | Pride
Shigella flexneri Label-free quantification Shigella sonnei. lc-ms/ms 
TranscriptomicsShigella flexneri ntrBC and nac mutant expression analysis
Investigate whole genome gene expression level changes in an S. flexneri ntrBC and nac mutants compared to wild type strain. NtrBC is a two component regulatory system, nac is a transcriptional activator Mutations in ntrBC and nac result in small plaque formation in Henle cell monolayers compared to...
ORGANISM(S): Shigella flexneri 
2014-05-09 | E-GEOD-49939 | biostudies-arrayexpress
ProteomicsProtein abundance comparison of human cells infected with Shigella flexneri over different time periods
The enteroinvasive bacterium Shigella flexneri invades the intestinal epithelium of humans. During infection, several injected effector proteins promote bacterial internalization, and interfere with multiple host cell responses. To obtain a systems-level overview of host signaling during infection, ...
ORGANISM(S): Homo sapiens (Human) 
2017-01-23 | PXD000219 | Pride
Infection Phosphoproteomics S. flexneri 
Proteomicsidentification of UFM1-dependent host effectors binding to Shigella flexneri in infectect HeLa cells
Host cells contest invasion by intracellular bacterial pathogens with multiple strategies that recognise and / or damage the bacterial surface. To identify novel host defence factors targeted to intracellular bacteria, we developed a versatile proximity biotinylation approach coupled to quantitative...
ORGANISM(S): Shigella flexneri Homo sapiens (Human) 
2026-08-17 | PXD075006 | Pride
Innate immunity Shigella flexneri Ufm1 
TranscriptomicsRNA polymerase inhibitor
Global transcriptional responses of shigella flexneri to RNA poly merase inhibitor We used two drugs with two concentration. At each concentration, there 3 time points.
ORGANISM(S): Shigella flexneri 
2012-03-21 | E-GEOD-32978 | biostudies-arrayexpress
GenomicsS. flexneri transcriptome in Henle-407 cells
S. flexneri transcriptome in Henle-407 cells
PRJNA489738 | ENA
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