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MetabolomicsBioplatforms Australia: Antibiotic Resistant Sepsis Pathogens Framework Initiative (Streptococcus pyogenes assays)

The Antibiotic Resistant Sepsis Pathogens Framework Initiative aims to develop a framework dataset of 5 sepsis pathogens (5 strains each) using an integrated application of genomic, transcriptomic, metabolomic and proteomic technologies. The pathogens included in this initiative are: Escheric...

2022-08-03 | MTBLS2324 | MetaboLights
MetabolomicsSmall Polar Hits against S. aureus: Screening, Initial Hit Optimization, and Metabolomic Studies
The global prevalence of antibacterial resistance requires new antibacterial drugs with novel chemical scaffolds and modes of action. It is also vital to design compounds with optimal physicochemical properties to permeate the bacterial cell envelope. We described an approach of combining and integr...
2021-11-04 | MTBLS788 | MetaboLights
ProteomicsDynamic protein phosphorylation in Streptococcus pyogenes during growth, stationary phase and starvation
The proteome and phosphoproteome of Streptococcus pyogenes M49 was investigated at different growth phases of cultures grown in either rich medium (THY), chemically defined medium without carbon source, or chemically defined medium containing 1% fructose. Of the 815 phosphosites identified, 463 were...
ORGANISM(S): Streptococcus pyogenes NZ131 Bacteria 
2024-05-22 | PXD044423 | Pride
Growth phases Phosphoproteome Label-free quantification Pasta kinase Streptococcus pyogenes m49 Proteome 
TranscriptomicsInsert in CovS Gene Distinguishes a Pharyngeal and a Blood Isolate of Streptococcus pyogenes Found in the Same Individual.
Expression of the extensive arsenal of virulence factors by Streptococcus pyogenes are controlled by many regulators, of which covR/S is one of the best characterized and can influence ~15% of the genome. Animal models have established that mutants of CovR/S arise spontaneously in vivo resulting in ...
ORGANISM(S): Streptococcus pyogenes 
2010-05-01 | E-GEOD-21316 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse macrophages in response to infection with Streptococcus pyogenes
The complex response of murine macrophages to infection with Streptococcus pyogenes was investigated at the level of gene expression using a high-density oligomer microarray. More than 400 genes were identified as being differentially regulated. Many of the up-regulated genes encoded molecules were ...
ORGANISM(S): Mus musculus 
2008-04-05 | E-GEOD-7769 | biostudies-arrayexpress
TranscriptomicsCounteractive balancing of transcriptome expression involving CodY and CovRS in Streptococcus pyogenes
Streptococcus pyogenes (group A Streptococcus, GAS) responds to environmental changes in a manner that results in an adaptive regulation of the transcriptome. Global transcriptional regulators are able to integrate important extracellular and intracellular information and are responsible for modulat...
ORGANISM(S): Streptococcus pyogenes NZ131 
2011-03-01 | E-GEOD-26590 | biostudies-arrayexpress
TranscriptomicsExpression analysis of Streptococcus pyogenes NZ131 serR-
Whole genone expression profile comparing wild-type NZ131 to serR deletion mutant, grown in C-medium Mutants and interpretation are described further in the manuscript to be submitted: LaSarre and Federle, 2010. Title: Regulation and Consequence of Serine Catabolism in Streptococcus pyogenes. A two ...
ORGANISM(S): Streptococcus pyogenes NZ131 
2010-11-15 | E-GEOD-24860 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of S. pyogenes Type M1-CdhA55(-) mutant
A total of 192 genes were found to be differentially expressed; 38 genes of them were up regulated and 154 genes were down regulated. Most notably the functional categories that were affected include carbohydrate metabolism and cell envelop realted genes ( 56, 29.1% of the total),Virulence genes (1...
ORGANISM(S): Streptococcus pyogenes 
2010-10-01 | E-GEOD-15598 | biostudies-arrayexpress
TranscriptomicsTranscriptomic comparison of serotype M1 S. pyogenes
S. pyogenes strains were compared with the intact covRS form of the globally disseminated M1T1 clone to track transcriptomic changes engendered during the emergence of the M1T1 clone. The mutant covRS form of the M1T1 clone was included as a transcriptomic outlier and to provide a context for the m...
ORGANISM(S): Streptococcus pyogenes 
2012-08-21 | E-GEOD-35568 | biostudies-arrayexpress
ProteomicsThe proteomic and transcriptomic landscapes altered by Rgg2/3 activity in Streptococcus pyogenes
Streptococcus pyogenes, otherwise known as Group A Streptococcus (GAS), is an important and highly adaptable human pathogen with the ability to cause both superficial and severe diseases. Understanding how S. pyogenes senses and responds to its environment will likely aid in determining how it cause...
ORGANISM(S): Streptococcus pyogenes NZ131 
2022-10-04 | PXD033703 | Pride
Rgg3 Streptococcus pyogenes Rgg2 Quorum sensing 
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