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Effect of serum amyloid A1 (SAA1) on gene expression in primary murine macrophages
Macrophages are important regulators of the immune system and are critically involved in the pathophysiology of many diseases. Serum amlyoidosis is a protein misfolding disease which can follow chronic inflammatory conditions. Deposition of fibrils formed from serum amyloid A1 (SAA1) protein occurs ...
ORGANISM(S): Mus musculus 
2021-07-20 | GSE155278 | GEO
Sepsis-associated acute kidney injury (SA-AKI) is highly lethal with a rapid onset, and effective drugs for treatment are lack due to the molecular pathogenesis underlying SA-AKI remains elusive. Tubular epithelial cells (TECs) have increasingly been recognized as a driving force in the progression ...
ORGANISM(S): Mus Musculus 
2024-08-22 | PXD055037 |
Temporal programming of T-helper 17 (TH17) cell differentiation by SAA1+IL6 measured by RNA-Seq
Objectives: Systemic inflammation is a major risk factor for critical-illness myopathy (CIM) but its pathogenic role in muscle is uncertain. We observed that interleukin 6 (IL-6) and serum amyloid A1 (SAA1) expression was upregulated in muscle of critically ill patients. To test the relevance of the...
ORGANISM(S): Homo sapiens 
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