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ProteomicsNovel protein biomarkers of monoamine metabolism defects correlate with disease severity
Background: Genetic defects of monoamine neurotransmitters are rare neurological diseases amenable to treatment with variable response. They are major causes of early parkinsonism and other spectrum of movement disorders including dopa-responsive dystonia. Objectives: To conduct proteomic studies i...
ORGANISM(S): Homo sapiens (Human) 
2020-11-16 | PXD021642 | Pride
Proteomics Monoamine metabolism defects 
ProteomicsPro-cognitive treatments restore hippocampal proteomic and kinome alterations in Ts65Dn mice
Down syndrome is the main genetic cause of intellectual disability and is due to triplication of human chromosome 21 (HSA21). Green tea extracts containing epigallocatechin-3-gallate (green tea) improve cognition both in mouse models and individuals with Down syndrome. We here analyzed the proteome ...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-13 | PXD018515 | Pride
Hippocampus Phosphoproteome Mouse Ts65dn Proteome 
ProteomicsStepwise emergence of the neuronal gene expression program in early animal evolution
The assembly of the neuronal and other major cell type programs occurred early in animal evolution. We can reconstruct this process by studying non-bilaterians like placozoans. These small disc-shaped animals have only nine morphologically described cell types and no neurons, but show coordinated be...
ORGANISM(S): Trichoplax sp. H2 Hoilungia hongkongensis 
2023-11-10 | PXD042821 | Pride
Mass spectrometry Evolution Neuropeptides 
ProteomicsBeauveria bassiana manipulates host plant physiology to promote growth and defense
During plant life, roots support beneficial associations with soil inhabiting microbes, mainly fungi and bacteria. Increasing evidence suggests that plant-associated microorganisms can promote plant growth and expand immune functions of the plant host. The beneficial entomopathogenic fungus Beauveri...
ORGANISM(S): Solanum lycopersicum 
2023-05-09 | PXD029422 | Pride
Proteomics Beauveria bassiana Tomato leaves Solanum lycopersicum l. Mass-spectrometry 
ProteomicsMSstats splitplot method for protein quantitation in MS datasets-SRM controlled mixture
Digested Escherichia coli protein extract were mixed with 89 different isotopically-labelled reference heavy peptides (5 pmol, 15N2,13C6-Lys, 15N4,13C6-Arg), and with different amounts of the corresponding light peptides (10 pmol, 5 pmol, 2.5 pmol), as 1, 2 and 4, respectively. Light peptides were d...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2019-08-21 | MSV000084220 | MassIVE
ProteomicsThe high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate cancer signaling pathways.
High mobility group proteins are chromatin regulators with essential functions in development, cell differentiation and cell proliferation. The protein HMG20A contains three well defined domains: an amino terminal intrinsically distorted domain, a high mobility group box with higher affinity for dou...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD030769 | Pride
Cancer High mobility group proteins 
Proteomicsran asters proteomics - Proteomic profiling of microtubule self-organization in M-phase
The main proteomics events driving the self-organization of MTs in M-phase cytoplasms are determined by obtaining the full proteomes of the RanGTP induced MT structures at different time points in Xenopus egg extracts.
ORGANISM(S): Xenopus laevis (African clawed frog) 
2018-07-11 | PXD008306 | Pride
Ran asters proteomics 
ProteomicsRescuing discarded spectra: Full comprehensive analysis of a minimal proteome.
A common problem encountered when performing large-scale mass spectrometry proteome analysis is the loss of information due to the high percentage of unassigned spectra. To determine the causes behind this loss we have analyzed the proteome of one of the smallest living bacteria that can be grown ax...
ORGANISM(S): Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
2016-01-05 | PXD002779 | Pride
Translation errors : mass spectroscopy Post-translational modifications (ptms) Protein identification Proteome coverage Unassigned spectra 
ProteomicsThe profiling of extracellular vesicle subtypes in Huntington’s disease brains identifies Alix as a novel marker of neuropathology
Background: Huntington’s disease (HD) is an inherited autosomal dominant disorder characterized by progressive degeneration of the striatum and cerebral cortex, caused by a mutation in the huntingtin gene, which includes an aberrant expansion of a CAG repeat. The mutant huntingtin protein accumulate...
ORGANISM(S): Homo sapiens (Human) 
2025-12-10 | PXD060574 | Pride
Mass spectrometry Extracellular vesicles Huntington’s disease 
ProteomicsMelanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis
RNA-binding proteins (RBPs) have been relatively overlooked in cancer research despite their contribution to virtually every cancer hallmark. Here, we use RNA interactome capture(RIC) to characterize the melanoma RBPome and uncover novel RBPs involved in melanoma progression. Comparison of RIC profi...
ORGANISM(S): Homo sapiens (Human) 
2022-07-19 | PXD029927 | Pride
Rbp Mass spectrometry Melanoma 
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