Sort   by:  
 Page size 
ProteomicsPro-cognitive treatments restore hippocampal proteomic and kinome alterations in Ts65Dn mice
Down syndrome is the main genetic cause of intellectual disability and is due to triplication of human chromosome 21 (HSA21). Green tea extracts containing epigallocatechin-3-gallate (green tea) improve cognition both in mouse models and individuals with Down syndrome. We here analyzed the proteome ...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-13 | PXD018515 | Pride
Hippocampus Phosphoproteome Mouse Ts65dn Proteome 
TranscriptomicsTranscription profiling of Ts65Dn vs control mice in nine different mouse tissues
To understand the molecular basis of Down syndrome pathogenesis, we performed a transcriptome analysis of nine different tissues in Ts65Dn, an established mouse model of human trisomy 21. Ts65Dn mice have segmental trisomy of mouse chromosome 16 with ca. 128 genes at dosage imbalance (Reeves et al. ...
ORGANISM(S): Mus musculus 
2004-04-23 | E-MEXP-102 | biostudies-arrayexpress
TranscriptomicsAffymetrix expression arrays from heart extracted RNA in Ts65Dn and Ms5Yah and Ts65DnMs5Yah mouse models
Affymetrix Mouse Gene 1.0 ST hydridization using wt extracts from adult mice hearts as controls and Ts65Dn, Ms5Yah and Ts65Dn/Ms5Yah samples.

N = 5 mices per group of genotype.

Goal : assess the gene dosage effect on partial trisomic/monosomic mice modelling human Down syndrome.
ORGANISM(S): Mus musculus 
2011-10-05 | E-MEXP-3355 | biostudies-arrayexpress
TranscriptomicsExpression of Cell Cycle related genes in developing mouse cerebellum
The goal of the study was to analize expression of cell cycle related genes during postnatal development of Ts65Dn (Down syndrome mouse model) and control mice cerebellum. Keywords: Gene expression study in mouse model of disease RNA from 3 controls and 3 Ts65Dn postnatal day 2 cerebellum were anali...
ORGANISM(S): Mus musculus 
2008-05-18 | E-GEOD-9216 | biostudies-arrayexpress
GenomicsTranscriptome from mouse Ts65Dn adult hippocampi and entorhinal cortices
Transcriptome from mouse Ts65Dn adult hippocampi and entorhinal cortices
PRJNA881248 | ENA
GenomicsTranscriptomics of Ts65Dn mice with viral-mediated overexpression of miR-200b
Transcriptomics of Ts65Dn mice with viral-mediated overexpression of miR-200b
PRJNA822391 | ENA
ProteomicsQuantitative Proteomics of Intracellular Traffic in Down Syndrome Brain
The effect of fluoxetine on the proteome of synaptic fractions of cerebral cortex tissue of male Ts65Dn mice was compared to the effect in euploid mice.
ORGANISM(S): Mus musculus (Mouse) 
2024-05-21 | PXD048722 | Pride
Down syndrome Mose Fluoxetine Cerebral cortex 
GenomicsPostnatal day 6 cerebellum of Ts65Dn and TcMAC21 Down syndrome mouse models
Postnatal day 6 cerebellum of Ts65Dn and TcMAC21 Down syndrome mouse models
PRJNA837794 | ENA
TranscriptomicsSkeletal muscle gene expression data from Down syndrome mice
Persons with Down syndrome (DS) exhibit low muscle strength that significantly impairs their physical functioning. The Ts65Dn mouse model of DS also exhibits muscle weakness in vivo and may serve as a useful model to examine potential factors responsible for DS-associated muscle dysfunction. Therefo...
ORGANISM(S): Mus musculus 
2013-01-06 | E-GEOD-39159 | biostudies-arrayexpress
UnknownCholinergic Senescence in the Ts65Dn Mouse Model for Down Syndrome.
Not available
S-EPMC9470680 | biostudies-literature
Sort   by:  
 Page size