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TranscriptomicsTranscription profiling of mouse hippocampus after chronic fluoxetine treatment
Both the mechanism of action and the factors determining the behavioral response to antidepressants are unknown. It has been shown that antidepressant treatment promotes the proliferation and survival of hippocampal neurons via enhanced serotonergic signaling, but it is still unclear whether hippoca...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6476 | biostudies-arrayexpress
TranscriptomicsDanio rerio larvae exposed to SSRIs Fluoxetine and Sertraline
Pharmaceutical chemicals used in human medicine are released into surface waters via municipal effluents and pose a risk for aquatic organisms. Among these substances are selective serotonin reuptake inhibitors (SSRIs) which can affect aquatic organisms at sub ppb concentrations. To better underst...
ORGANISM(S): Danio rerio 
2012-09-06 | E-GEOD-31712 | biostudies-arrayexpress
TranscriptomicsAuratus goldfish genome project: effects of fluoxetine on female goldfish
A goldfish brain enriched cDNA combined with a carp microarray (Gracey et al., 2004). Female adult goldish were treated twice a week for 17 days, for a total of five injections. Each of the injections consisted of 5 μg fluoxetine/g of body weight with an injection volume of 1μl/g. The telencepha...
ORGANISM(S): Carassius auratus 
2010-07-01 | E-GEOD-5420 | biostudies-arrayexpress
TranscriptomicsThe antidepressant fluoxetine elicits anticancer effects by impairing aerobic glycolysis in colon cancer cells and xenografts.
Colon cancer is one of the most common tumors worldwide. Recent reports showed that patients treated with the antidepressant fluoxetine had reduced colon cancer risk, with effects similar to the chemotherapeutic 5-fluoro-uracil. Here, we examined the effects of fluoxetine and 5-fluoro-uracil on gene...
ORGANISM(S): Homo sapiens 
2015-06-09 | E-GEOD-51904 | biostudies-arrayexpress
Proteomics12_pharmacometabolomics_depression_DF
We carried out untargeted metabolomics of the prefrontal cortex of rats exposed to chronic social isolation (CSIS), a rat model of depression, and/or fluoxetine treatment using liquid chromatography-high resolution mass spectrometry.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2023-06-05 | MSV000092101 | MassIVE
TranscriptomicsGene expression of Lymphoblastoid Cell Lines (LCLs) from Depressed Patients after in-vitro treatment with fluoxetine
We used whole gene gene expression profiling to identify potential gene expression biomarkers associated for the treatment individualization of depressive disorders. Gene expression was measured after 21 days of in-vitro treatment with therapeutical concentrations of fluoxetine in n=10 LCLs derived ...
ORGANISM(S): Homo sapiens 
2016-06-15 | E-GEOD-83386 | biostudies-arrayexpress
Transcriptomicspostnatal fluoxetine evoked gene expression changes in the rat hippocampus
to understand the consequences of chronic exposure to fluoxetine during postnatal life on global transcriptional changes withing the rat hippocamps Agilent one-color experiment,Organism: Rattus Norvegicus, Agilent-016352 Genotypic designed Custom Rattus Norvegicus 8x15k, Labeling kit: Agilent Quic...
ORGANISM(S): Rattus norvegicus 
2013-12-01 | E-GEOD-42940 | biostudies-arrayexpress
TranscriptomicsMolecular regulation in the hippocampal dentate gyrus in the onset and treatment of depression
Major depression is a multidimensional disorder highly prevalent in modern society. Although several classes of antidepressants (ADs) are currently available to treat depression, the effectiveness of treatment is still limited, as many patients do not show full remission; thus, there is a need to fi...
ORGANISM(S): Rattus norvegicus 
2015-07-02 | E-GEOD-56028 | biostudies-arrayexpress
TranscriptomicsGene Expression Data Following Chronic Vehicle or Fluoxetine Treatment in Thirty Mouse Inbred Lines
In order to understand how biochemical and genetic differences correlate with treatment response, we measured depressive-like behavior, gene expression and the levels of thirty-six neurobiochemical analytes across a panel of genetically-diverse mouse inbred lines after chronic treatment with vehicle...
ORGANISM(S): Mus musculus 
2011-08-30 | E-GEOD-28644 | biostudies-arrayexpress
TranscriptomicsEffect of fluoxetine treatment on translational profiles of Glt25d2 cortical pyramidal cells
Molecular phenotyping of cell types and neural circuits underlying pathological neuropsychiatric conditions and their responses to therapy provides one avenue for the development of more specific and effective treatments. In this study, we identify a cell population in the cerebral cortex that shows...
ORGANISM(S): Mus musculus 
2012-05-31 | E-GEOD-35763 | biostudies-arrayexpress
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