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ProteomicsLztr1 loss leads to Noonan syndrome-like vascular defects by dysregulating vesicular trafficking
Mutations in LZTR1, an adaptor for cullin 3 (CUL3) ubiquitin ligase complex, are associated with glioma, hepatocarcinoma, paediatric cancers, Schwannomatosis, and Noonan syndrome (NS). NS is a poorly understood and complex disease. The variety of NS phenotypes makes it challenging to elucidate the m...
ORGANISM(S): Homo sapiens (Human) 
2020-10-14 | PXD011926 | Pride
Hela cells Vegf Noonan syndrome Lztr1 Vesicular trafficking Ubiquitin Chmp1b 
ProteomicsLoss-of-function of ubiquitin ligase adaptor LZTR1 triggers human disease by dysregulating RAS ubiquitination
Mutations in LZTR1, a substrate adaptor for cullin 3 (CUL3) ubiquitin ligase complexes, have been recently associated with Noonan syndrome and familial Schwannomatosis. Concordantly, we found that Lztr1+/- mice showed craniofacial abnormalities, cardio defects, and premature ageing; whereas loss of ...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-07 | PXD007035 | Pride
Ras signalling Schwannomatosis Noonan syndrome Ubiquitin 
ProteomicsStress-induced lncRNA LAS3 fosters fitness of cancer cells by regulating SART3-mediated spliceosome recycling
Long non-coding RNAs (lncRNAs) represent a novel class of anti-cancer therapeutic targets. Hypoxia-induced lncRNAs are associated with the aggressive tumor phenotypes and might serve as putative drug targets. Here, we unraveled lncRNAs whose expression is upregulated in hypoxic breast tumors. One of...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD013334 | Pride
Breast cancer Hypoxia Sart3 Intron retention Long non-coding rnas 
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