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ProteomicsStress-induced lncRNA LAS3 fosters fitness of cancer cells by regulating SART3-mediated spliceosome recycling
Long non-coding RNAs (lncRNAs) represent a novel class of anti-cancer therapeutic targets. Hypoxia-induced lncRNAs are associated with the aggressive tumor phenotypes and might serve as putative drug targets. Here, we unraveled lncRNAs whose expression is upregulated in hypoxic breast tumors. One of...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD013334 | Pride
Breast cancer Hypoxia Sart3 Intron retention Long non-coding rnas 
ProteomicsSART3 is a Novel Rme2s Reader studied by tandem MS
Arginine methylation is a ubiquitous post-translational modification involved in many biological processes such as transcription, cell signaling and RNA splicing. Tudor domains by far are the major effector domain family for arginine methylation mark recognition. Here we characterize SART3 as a nove...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD046708 | Pride
Apms Lcms Arginine methylation 
GenomicsSART3 is a Novel Rme2s Reader
SART3 is a Novel Rme2s Reader
PRJNA1033193 | ENA
ProteomicsSART3 promotes homologous recombination repair by stimulating DNA–RNA hybrids removal and DNA end resection
DNA–RNA hybrids triggered by double-strand breaks (DSBs) are crucial intermediates during DSB repair, and their timely resolution requires numbers of RNA helicases, including DEAD box 1 (DDX1). However, how these helicases are recruited to DSB-induced hybrids in time remains largely unclear. Here, w...
ORGANISM(S): Homo sapiens (Human) 
2025-01-30 | PXD053595 | Pride
Sart3 Homologous recombination repair Dna–rna hybrids 
ProteomicsIdentification of SART3 as a pre-miR-34a–binding protein
MicroRNAs (miRNAs or miRs) are small, noncoding RNAs that are implicated in the regulation of nearly all biological processes. Global miRNA biogenesis is altered in many cancers and RNA-binding proteins (RBPs) have been shown to play a role in this process, presenting a promising avenue for targetin...
ORGANISM(S): Homo sapiens (Human) 
2019-10-14 | PXD015278 | Pride
Proteomics Sart3 Mirna Rbps Mir34 
ProteomicsSART3 is a Novel Rme2s Reader studied by tandem MS
Arginine methylation is a ubiquitous post-translational modification involved in many biological processes such as transcription, cell signaling and RNA splicing. Tudor domains by far are the major effector domain family for arginine methylation mark recognition. Here we characterize SART3 as a nove...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD044862 | Pride
Sart3 Hat(half-a-tpr) Rna splicing Rme2s reader Arginine methylation 
OtherSART3 is a Novel Rme2s Reader
Arginine methylation is a ubiquitous post-translational modification involved in many biological processes such as transcription, cell signaling and RNA splicing. Tudor domains by far are the major effector domain family for arginine methylation mark recognition. Here we characterize SART3 as a nove...
ORGANISM(S): Homo sapiens 
2024-10-01 | GSE246489 | GEO
ProteomicsVariants in SART3 cause a novel spliceosomopathy characterised by failure of testis development and neuronal defects
Squamous cell carcinoma antigen recognized by T cells 3 (SART3) is an RNA binding protein that regulates a diverse array of biological processes, including recycling small nuclear ribonucleic acids (snRNAs) back to the spliceosome. Here we describe nine individuals from six independent families with...
ORGANISM(S): Homo sapiens (Human) 
2023-06-11 | PXD032816 | Pride
Gonadal dysgenesis 46 Neurodevelopmental disorder Spliceosome Xy dsd Sart3 Tip110 
UnknownRNA-splicing factor SART3 regulates translesion DNA synthesis.
Not available
S-EPMC5961147 | biostudies-literature
GenomicsThe spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway
The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway
PRJNA756891 | ENA
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