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TranscriptomicsMolecular signatures of human iPSCs highlight sex differences and cancer genes
We compared human female hiPSC lines (all derived from IMR-90 fibroblasts) that were XIST RNA-positive and XIST RNA-negative. We also examined the gene expression patterns for 2 female hIPSCs (derived from different disease model fibroblasts) that were also negative for XIST RNA. hiPS 12D-1 is deri...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-36233 | biostudies-arrayexpress
GenomicsX-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription
Dosage compensation in mammals occurs at two levels. In addition to balancing X-chromosome dosage between males and females via X-inactivation, mammals also balance dosage of Xs and autosomes. It has been proposed that X-autosome equalization occurs by upregulation of Xa (active X). To investigate t...
ORGANISM(S): Mus musculus 
2012-01-06 | E-GEOD-33823 | biostudies-arrayexpress
TranscriptomicsXist RNA is a potent suppressor of hematologic cancer in mice.
X-chromosome aneuploidies have long been associated with human cancers, but causality has not been established. In mammals, X-chromosome inactivation (XCI) is triggered by Xist RNA to equalize gene expression between the sexes. Here we delete Xist in the blood compartment of mice and demonstrate tha...
ORGANISM(S): Mus musculus 
2013-02-20 | E-GEOD-43961 | biostudies-arrayexpress
GenomicsSpreading of X-chromosome inactivation via a hierarchy of defined Polycomb stations
Binding of Polycomb repressive complex 2 (PRC2) and chromatin composition of the inactive X (Xi) before, during and after X chromosome inactivation reveal that spreading is driven by a combination of Xi-specific strong and moderate Ezh2 sites. Sequence context of these sites shows a moderate enrichm...
ORGANISM(S): Mus musculus 
2012-11-01 | E-GEOD-36905 | biostudies-arrayexpress
TranscriptomicsInhibiting Fungal Multidrug Resistance by Disrupting an Activator-Mediator Interaction With the Small Molecule iKIX1
Eukaryotic transcription activators stimulate the expression of specific sets of target genes through recruitment of co-activators such as the RNA polymerase II-interacting Mediator complex. We previously identified an activator-targeted ~85 amino acid three-helix bundle KIX domain in the human MED1...
ORGANISM(S): Saccharomyces cerevisiae 
2015-12-15 | E-GEOD-74361 | biostudies-arrayexpress
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