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TranscriptomicsSAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells
The scaffold attachment factors SAFB1 and SAFB2 are paralogs, which are involved in cell cycle regulation, apoptosis, differentiation, and stress response. They have been shown to function as estrogen receptor co-repressors, and there is evidence for a role in breast tumorigenesis. To identify their...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-15548 | biostudies-arrayexpress
UnknownScaffold attachment factor B2 (SAFB2)-null mice reveal non-redundant functions of SAFB2 compared with its paralog, SAFB1.
Not available
S-EPMC4582101 | biostudies-literature
UnknownNo germline mutations in supposed tumour suppressor genes SAFB1 and SAFB2 in familial breast cancer with linkage to 19p.
Not available
S-EPMC2635354 | biostudies-literature
GenomicsEffects of CRISPR/Cas9-mediated deletion of Safb1 and Safb2 genes on the mature miRNA transcriptome
Effects of CRISPR/Cas9-mediated deletion of Safb1 and Safb2 genes on the mature miRNA transcriptome
PRJNA592072 | ENA
GenomicsEffect of SAFB1/SAFB2 knockou or ERH knockout on the miRNA transcriptome of murine Baf3 cells
Effect of SAFB1/SAFB2 knockou or ERH knockout on the miRNA transcriptome of murine Baf3 cells
PRJNA1368876 | ENA
GenomicsEffect of SAFB1/SAFB2 knockou or ERH knockout on the miRNA transcriptome of murine Baf3 cells
MicroRNAs are small non-coding RNAs that mediate post-transcriptional silencing of most mammalian genes. They are generated in a multi-step process initiated by the Microprocessor, a protein complex composed of DROSHA and DGCR8. Recent studies have described the phenomenon of “cluster assistance”, i...
ORGANISM(S): Mus musculus 
2025-12-05 | GSE311272 | GEO
GenomicsEffects of CRISPR/Cas9-mediated deletion of Safb1 and Safb2 genes on the mature miRNA transcriptome
MicroRNAs (miRNAs) are 20-25 nucleotides (nt) RNAs that are predicted to post-transcriptionally silence expression of >60% of all protein coding genes in mammals. As such, they form an additional layer of gene regulation that controls most if not all biological processes. MiRNAs are generated from p...
ORGANISM(S): Homo sapiens 
2019-11-28 | GSE141098 | GEO
ProteomicsHypoxia-induced subnuclear re-distribution of SAFB1/2 alters their respective interactome
Oxygen deprivation (hypoxia) is encountered in physiological conditions but also characterizes many pathological conditions including ischemia and cancer. In order to survive, the cells usually rely upon the activation of the Hypoxia Inducible Factors (HIF), a small family of heterodimeric transcrip...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD030933 | Pride
Safb2 Nuclear matrix Splicing Hypoxia Scaffold attachment factor Safb1 
TranscriptomicsshRNA RNA-seq from HepG2 (ENCSR110ZYD)
shRNA knockdown against SAFB2 in HepG2 cells followed by RNA-seq. (SAFB2-57-BGHLV20) For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf
ORGANISM(S): Homo sapiens 
2016-11-08 | GSE88040 | GEO
TranscriptomicsSAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells
The scaffold attachment factors SAFB1 and SAFB2 are paralogs, which are involved in cell cycle regulation, apoptosis, differentiation, and stress response. They have been shown to function as estrogen receptor co-repressors, and there is evidence for a role in breast tumorigenesis. To identify their...
ORGANISM(S): Homo sapiens 
2010-01-28 | GSE15548 | GEO
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