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ProteomicsHigh glucose treatment promotes extracellular matrix proteome remodeling in Müller glial cells
The underlying pathomechanisms in diabetic retinopathy (DR) remains incompletely understood. The aim of this study was to add to the current knowledge about the particular role of retina Müller glial cells (RMG) in the initial processes of DR. Applying a mass spectrometric workflow, we investigated ...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-04-06 | PXD015879 | Pride
Inner limiting membrane (ilm) Diabetic retinopathy (dr) Extracellular matrix (ecm) Müller cells (rmg) Hyperglycemia Secreted phosphoprotein 1 (spp1) Neurodegeneration 
ProteomicsNeuroretinal-derived caveolin-1 promotes endotoxin-induced inflammation in the murine retina
Chronic ocular inflammation is associated with many retinal degenerative diseases that result in vision loss. The immune-privileged environment and complex organization of retinal tissue allow for the retina’s essential role in visual function processes, yet confound inquiries into cell-specific inf...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD016872 | Pride
Caveolin-1  caveolin  caveolae  inflammation  neural retina  retina  retinal degeneration  immune response 
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