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TranscriptomicsU937 scramble vs shHDAC2 upon SAHA (Vorinostat; suberoylanilide hydroxamic acid) treatment
Transcriptional profiling of U937 scramble vs shHDAC2 before and after SAHA treatment at 5µM concentration for 6 and 24 hours. Different Experimental Conditions: U937 scramble (U937 trasfected with empty vector) vs shHDAC2 (U937 trasfected with shHDAC2 vector), untreated and treated with SAHA at 5 ...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-37529 | biostudies-arrayexpress
TranscriptomicsExpression data from SKOV3 cells treated with SAHA or vehicle control
We performed a microarray experiment to assess SAHA-induced changes in expression of genes of the homologous recombination DNA repair pathway SKOV-3 ovarian cancer cells were treated with 1µM SAHA or vehicle-control (0.01% DMSO) for 6 or 24 hours, harvested and processed for RNA isolation. Data fo...
ORGANISM(S): Homo sapiens 
2014-03-19 | E-GEOD-53603 | biostudies-arrayexpress
ProteomicsAn integrated systems biology approach reveals positive and negative effects of suberoylanilide hydroxamic acid (SAHA) on HIV reactivation from latency
Suberoylanilide hydroxamic acid (SAHA) has been assessed in clinical trials as part of a “shock and kill” strategy to cure HIV-infected patients. While it was effective at inducing expression of HIV RNA "shock" , treatment with SAHA did not result in the reduction of reservoir size "kill". We theref...
ORGANISM(S): Homo sapiens (Human) 
2015-09-10 | PXD002150 | Pride
Human Hiv latency Cd4 t-cells Saha Suberoylanilide hydroxamic acid 
TranscriptomicsGenome-wide analysis of parental and wild-type SK-N-Be(2)C neuroblastoma cell lines as well as those co-treated with the histone deacetylase inhibitor SAHA
Analysis of varied biologic pathways in neuroblastoma SK-N-Be(2)C cells grown in doxorubicin and/or SAHA. We hypothesized that SK-N-Be(2)C cells undergo a mesenchymal change through mesenchymal change resulting in a more invasive as well as drug resistant phenotype, and that the mechanism of SAHAs e...
ORGANISM(S): Homo sapiens 
2016-05-31 | E-GEOD-47669 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of T84 colorectal carcinoma cells treated with receptor guanylyl cyclace C agonist (stable toxin)
Receptor guanylyl cyclase C (GC-C) is expressed in the intestinal epithelia and plays a key role in intestinal physiology. Activation of GC-C by its ligands has been shown to regulate proliferation and differentiation of enterocytes along the crypt-villus axis. This study aims to identify genes regu...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-45531 | biostudies-arrayexpress
TranscriptomicsExpression data from human hepatic stellate cell line LX2 treated with suberoylanilide hydroxamic acid (SAHA) or valproic acid (VPA)
Suberoylanilide hydroxamic acid (SAHA) and valproic acid (VPA) are both histone deacetylases inhibitor (HDACi), and are able to attenuate the activation of hepatic stelllate cells. To explore the underlying molecular mechanisms, we performed gene expression profile analyses of human hepatic stellate...
ORGANISM(S): Homo sapiens 
2016-04-07 | E-MTAB-3764 | biostudies-arrayexpress
ProteomicsEpigenetic Impairment of tumor potential of AML-derived extracellular vesicles
The biological active cargo of leukemia-derived extracellular vesicles (EVs) favours a wide variety of cancer-supportive mechanisms, including aberrant proliferative signalling, immune escape and drug resistance. However, whether and in which extent anti-neoplastic drugs affect EV cargo sorting is ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD042168 | Pride
Vesicle Leukemia Tumorigenicity Epigenetic Saha 
TranscriptomicsGlobal mRNA expression profiling of murine primary PDAC cells following JQ1 or SAHA monotherapy as well as JQ1-SAHA combination therapy
Global mRNA expression profiles of murine primary PDAC cells following JQ1 or SAHA monotherapy as well as JQ1-SAHA combination therapy were collected using Affymetix mouse whole genome array (Mouse Genome 430A 2.0 Array) . Primary PDAC cells isolated from Ptf1aCre/+;Kras+/LSL-G12D;p53lox/lox (Kras;p...
ORGANISM(S): Mus musculus 
2015-09-20 | E-GEOD-64836 | biostudies-arrayexpress
TranscriptomicsPrimary human erythroid progenitor cells SAHA treatment samples
Gene expression profiling was performed on primary human erythroid progenitor cells left untreated or treated with 0.5uM SAHA. The worldwide burden of sickle cell disease is enormous, with over 200,000 infants born with the disease each year in Africa alone. Induction of fetal hemoglobin is a valida...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-22367 | biostudies-arrayexpress
TranscriptomicsPatterns of changes in DNA global methylation following the treatment with GC/RA and with GC/RA plus AZA/SAHA in MYC amplified and BRG1 mutant lung cancer cell lines
Comprehensive characterization of the DNA methylome regulated by the treatment with glucocorticoids (GC) and retinoic acid (RA) alone and combined with AZA/SAHA and the relationship of these features with the status of BRG1 and MYC in lung cancer cell lines. MYC amplified cell lines and BRG1 mutant ...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-66087 | biostudies-arrayexpress
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