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TranscriptomicsHuman MAIT and CD8++ cell development
This SuperSeries is composed of the following subset Series: GSE33374: Expression data from healthy human CD161++CD8aa and CD161++CD8ab T cells GSE33424: Expression data from human cord blood CD161++/CD161+/CD161- CD8+ T cell subsets Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-01-25 | E-GEOD-33425 | biostudies-arrayexpress
TranscriptomicsThe histone demethylase JMJD1A is essential to prostate cancer cells through regulation of c-Myc expression
Analysis of gene expresssion altered upon knockdown of histone demethylase JMJD1A in human prostate cancer cells. The objective is to elucidate the transcriptional programs that are controlled by JMJD1A in human prostate cancer. CWR22Rv1 prostate cancer cells were transduced with lentiviral particle...
ORGANISM(S): Homo sapiens 
2015-09-08 | E-GEOD-70498 | biostudies-arrayexpress
TranscriptomicsGene array experiment to identify genes that are upregulated by saturating creatine levels in vitro and potentially inhibiting creatine transporter (CrT) activity
We sought to investigate the mechanisms of CrT modulation by saturating extracellular Cr. For this purpose, we used an in vitro system of 3T3 fibroblasts stably overexpressing CrT and followed a global gene array approach to test the hypothesis that saturating intracellular [Cr] increases the expres...
ORGANISM(S): Mus musculus 
2012-12-07 | E-GEOD-42356 | biostudies-arrayexpress
TranscriptomicsThe role of HIF in FH-associated renal neoplasia
Fumarate hydratase (FH) mutations predispose to renal cysts cancer. These cancers overexpress hypoxia-inducible factor-alpha (Hif-1a). We have generated a conditional Fh1 (mouse FH) knockout mice that develop renal cysts and overexpress Hif-1a. In order to identify the contribution of Hif-1a to cyst...
ORGANISM(S): Mus musculus 
2011-10-23 | E-GEOD-29988 | biostudies-arrayexpress
TranscriptomicsExpression data from healthy human CD161++CD8aa and CD161++CD8ab T cells
We used microarrays to compare gene expression between healthy human CD161++CD8aa and CD161++CD8ab T cells. We sorted freshly obtained peripheral blood mononucleocytes from healthy controls by first using magnetic beads to negatively select for CD8a+ T cells, fluorescently labelling isolated cells w...
ORGANISM(S): Homo sapiens 
2012-01-25 | E-GEOD-33374 | biostudies-arrayexpress
TranscriptomicsExpression data from human cord blood CD161++/CD161+/CD161- CD8+ T cell subsets
We used microarray to compare gene expression between CD161++/CD161+/CD161-CD8+ T cells from human cord blood. Lymphocytes from freshly obtained human cord blood samples were isolated by Ficoll density centrifugation. CD8+ T cells were purified by negative selection using magnetic beads and subseque...
ORGANISM(S): Homo sapiens 
2012-01-25 | E-GEOD-33424 | biostudies-arrayexpress
TranscriptomicsThe E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity
Analysis of gene expression altered upon knockdown of Siah2 in prosate cancer cells. The objective is to elucidate which signaling pathways or transcription factors are regulated by the E3 ubiquitin ligase Siah2 in human prostate cancer cells. CWR22Rv1 cells were in fected with pLKO.1 control or Sia...
ORGANISM(S): Homo sapiens 
2013-03-19 | E-GEOD-38851 | biostudies-arrayexpress
TranscriptomicsThe E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity cancer.
The androgen receptor (AR) plays a central role in the development of castration resistant prostate cancer (CRPC). Here, we demonstrate that the ubiquitin ligase Siah2 targets a select pool of NCOR1-bound, transcriptionally inactive AR for ubiquitination dependent degradation, thereby promoting the ...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-GEOD-44319 | biostudies-arrayexpress
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