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High degree of metabolic heterogeneity and plasticity of triple-negative breast cancer (TNBC) contribute to its aggressiveness and resistance to standard therapies, necessitating identification of novel therapeutic vulnerabilities. Here, we identify non-canonical functions of an ECM remodeler protei...
ORGANISM(S): Homo sapiens (Human) 
2026-07-06 | PXD071741 | Pride
New targets and drugs for treatment of breast cancer are needed. We tested the effects of the TKI258 (Novartis) FGFR-inhibitor on tumor formation in mice. 4T1 mouse cell line, which had been derived from BALB/c mice, was injected into tail veins of BALB/c mice (syngraft model). Seven days later, mic...
ORGANISM(S): Mus musculus 
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