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MetabolomicsUntargeted metabolomic profiling of HCT116 cells following DHODH and JNK inhibition

Untargeted LC-MS metabolomics was used to investigate metabolic alterations associated with DHODH inhibition and JNK signaling in colorectal cancer. The study included control, DHODH inhibitor treated, JNK inhibitor treated, and combined treatment groups, with pooled quality control samples for a...

2026-08-13 | MTBLS15162 | MetaboLights
MetabolomicsIDH1 Reprograms Nucleotide Metabolism by Inducing Chromatin Remodeling and DHODH Transcription to Drive Chemoresistance in Nasopharyngeal Carcinoma

Metabolic reprogramming under therapeutic stress may represent a targetable vulnerability for cancer treatment. Elucidation of the metabolic alterations linked to chemotherapy in nasopharyngeal carcinoma (NPC) could uncover potential therapeutic strategies. Using proteomics and transcriptomic pro...

2026-01-14 | MTBLS11531 | MetaboLights
ProteomicsDHODH inhibition suppresses cutaneous squamous cell carcinoma growth by the induction of differentiation through perturbation of the cellular redox balance
Dihydroorotate dehydrogenase (DHODH), a key enzyme in de novo pyrimidine biosynthesis, has recently emerged as a therapeutic target in various cancers. We have previously identified a pivotal role of DHODH in initiation of cutaneous squamous cell carcinoma (cSCC), the second most common type of non-...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD070860 | Pride
Cscc Cutaneous squamous cell carcinoma Differentiation Pyrimidine biosynthesis Cancer therapy Dhodh 
ProteomicsDHODH is a synthetic-lethal vulnerability in BCOR-deficient acute myeloid leukemia
Acute Myeloid Leukemia (AML) remains challenging to treat, especially in cases with mutations in the BCL-6 co-repressor (BCOR), which are associated with poor prognosis and chemo-resistance. In this study, we reveal a synthetic lethal interaction between BCOR and dihydroorotate dehydrogenase (DHODH)...
ORGANISM(S): Homo sapiens (Human) 
2026-09-24 | PXD062779 | Pride
Acute myeloid leukemia Bcor Am Bcl-6 co-repressor 
GenomicsEffect of DHODH on gene expression in 4T1 cells
Effect of DHODH on gene expression in 4T1 cells
PRJNA911815 | ENA
GenomicsDHODH function
DHODH function
PRJNA911809 | ENA
ProteomicsRSDR, a Novel Potential Biomarker, Protects Against AKI by Interacting with hnRNPK to Regulate DHODH-Mediated Ferroptosis
Molecular analyses—including RNA immunoprecipitation, pull-down assays, mass spectrometry, and chromatin immunoprecipitation sequencing—demonstrated that RSDR and hnRNPK stabilize each other, forming a positive feedback loop that amplifies DHODH expression.
ORGANISM(S): Mus Musculus 
2025-03-19 | PXD062047 |
GenomicsEffect of DHODH inhibitor on gene expression in A549 cells
Effect of DHODH inhibitor on gene expression in A549 cells
PRJNA911813 | ENA
GenomicsEffect of DHODH inhibitor on gene expression in Panc1 cells
Effect of DHODH inhibitor on gene expression in Panc1 cells
PRJNA911817 | ENA
GenomicsDHODH regulates mitochondrial bioenergetics, methylation cycle, and DNA repair in Prostate Adenocarcinoma
DHODH regulates mitochondrial bioenergetics, methylation cycle, and DNA repair in Prostate Adenocarcinoma
PRJNA1306180 | ENA
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