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TranscriptomicsTranscription profiling of human cancer cells treated with unfolded protein response modulators under endoplasmic reticulum stress conditions
The unfolded protein response (UPR) is a cellular defense mechanism against glucose deprivation, a cell condition that occurs in solid tumors. A key feature of the UPR is the activation of the transcription program that allows the cell to cope with endoplasmic reticulum (ER) stress. We used micoarra...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-13548 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human bone marrow-derived sesenchymal stem cells with prolonged life span vs life span after neuronal induction
Primary culture of marrow-derived mesenchymal cells vs marrow-derived MSCs with a prolonged life span vs MSCs with a prolonged life span after neuronal induction.
ORGANISM(S): Homo sapiens 
2008-06-19 | E-GEOD-2110 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of wild-type and delta_dasR mutant of Streptomyces coelicolor grown in soil amended with chitin
Genome-wide microarray analysis was performed using RNA extracted from soil cultures of Streptomyces coelicolor A3(2) in the presence or absence of chitin. The vast majority of genes in chitin and amino sugar metabolism, as well as many other genes for carbon and energy, nitrogen and sulfur metaboli...
ORGANISM(S): Streptomyces coelicolor A3(2) 
2012-11-07 | E-GEOD-39164 | biostudies-arrayexpress
TranscriptomicsCompound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling.
Inhibiting the unfolded protein response (UPR) can be a therapeutic approach, especially for targeting the tumor microenvironment. We found that compound C (also known as dorsomorphin) prevented the UPR and exerted enhanced cytotoxicity during glucose deprivation. The UPR-inhibiting activity of comp...
ORGANISM(S): Homo sapiens 
2012-10-11 | E-GEOD-32911 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse EMT-induced and non-induced cells
The conversion of an epithelial cell to a mesenchymal cell is critical to vertebrate embryogenesis and a defining structural feature of organ development, such as forming fibroblasts in injured tissues, or in initiating metastases in epithelial cancer. From a general perspective, EMT is about disagg...
ORGANISM(S): Mus musculus 
2011-08-12 | E-GEOD-31359 | biostudies-arrayexpress
TranscriptomicsMitochondria help avoid glucose addiction in cancer cells
Cancer cells consume large amounts of glucose because of their specific metabolic pathway. However, cancer cells exist in tumor tissue where glucose is insufficient. To survive, cancer cells likely have the mechanism to elude their glucose addiction. Here we show that functional mitochondria are ess...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-16157 | biostudies-arrayexpress
ProteomicsProteome analysis of brain vessels (the anterior cerebral artery and the middle cerebral artery) from 24-month-old Htra1 KO and wild type mice
CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary cerebral small-vessel disease caused by loss of function mutations of HTRA1, which is a serine protease with a variety of targets, including extracellular matrix proteins. We isolate...
ORGANISM(S): Mus Musculus (mouse) 
2021-11-02 | PXD022298 | JPOST Repository
ProteomicsProteome analysis of brain vessels (the anterior cerebral artery and the middle cerebral artery) from 24-month-old candesartan-treated and nontreated Htra1 KO mice
CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary cerebral small-vessel disease caused by loss of function mutations of HTRA1, which is a serine protease with a variety of targets, including extracellular matrix proteins. Htra1-KO m...
ORGANISM(S): Mus Musculus (mouse) 
2021-11-16 | PXD023477 | JPOST Repository
UnknownNational trends in the outcomes of subarachnoid haemorrhage and the prognostic influence of stroke centre capability in Japan: retrospective cohort study.
Not available
S-EPMC10111904 | biostudies-literature
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