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TranscriptomicsKidney transplantation
In this study, we examined transcriptional profiles from 3 different microarray platforms, across 103 peripheral blood samples with and without acute rejection, to find a critical gene-set for the diagnosis of acute renal rejection that matched biopsy diagnosis, irrespective of patient demographics,...
ORGANISM(S): Homo sapiens 
2012-12-26 | E-GEOD-14067 | biostudies-arrayexpress
TranscriptomicsMechanical loading and gene expression - Microarray study
Skeletal integrity in humans and animals is maintained by daily mechanical loading. It has been widely accepted that osteocytes function as mechanosensors. Many biochemical signaling molecules are involved in the response of osteocytes to mechanical stimulation. The aim of this study was to identify...
ORGANISM(S): Rattus norvegicus 
2013-11-21 | E-GEOD-50707 | biostudies-arrayexpress
TranscriptomicsKidney gene expression in ANG and salt-induced heart failure
Balb/cJ and C57BL/6J were subjected to either 0.5µg/kg/min angiotensin II, 3% sodium diet, or the combination. Sham operated animals receiving a 0.3% sodium normal diet were used as controls.
ORGANISM(S): Mus musculus 
2019-04-15 | E-MTAB-3701 | biostudies-arrayexpress
GenomicsDistinctive Chromatin in Human Sperm Packages Genes that Guide Embryo Development: ChIP-seq
As nucleosomes are widely replaced by protamine in mature human sperm, epigenetic contributions to embryo development appear limited. However, our genome-wide approaches find nucleosomes at low levels genome-wide, but also significantly enriched at imprinted gene clusters, miRNA clusters, HOX gene...
ORGANISM(S): Homo sapiens 
2009-06-15 | E-GEOD-15690 | biostudies-arrayexpress
TranscriptomicsComparative gene expression profiling of human PGP1 iPS, lymphocyte, donor fibroblasts
Human iPS cell line, immortalized B-cells, and primary fibroblasts frome Personal Genome Project voluteer 1 Each sample per cell type.
ORGANISM(S): Homo sapiens 
2014-03-04 | E-GEOD-54733 | biostudies-arrayexpress
TranscriptomicsPromiscuous RNA binding by PRC2
Polycomb repressive complex-2 (PRC2) is a histone methyltransferase required for epigenetic silencing during development and cancer. Long non-coding RNAs (lncRNAs) recruit PRC2 to chromatin, but the general role of RNA in maintaining repressed chromatin is unknown. ChIP-seq, combined with RNA-seq, i...
ORGANISM(S): Homo sapiens 
2013-09-28 | E-GEOD-50177 | biostudies-arrayexpress
GenomicsChromatin-wide profiling of the protein kinase DYRK1A reveals a role as a transcriptional activator of cell growth related genes
DYRK1A is a dosage-sensitive protein kinase that fulfills key roles during development and in tissue homeostasis, and its dysregulation results in human pathologies. DYRK1A is present in both the nucleus and cytoplasm of mammalian cells, although its nuclear function remains unclear. Genome-wide ana...
ORGANISM(S): Homo sapiens 
2015-03-11 | E-GEOD-63712 | biostudies-arrayexpress
GenomicsChIP-seq analysis of H3K9me3 levels across the genome for one copy of H3K9M mutant in pombe
We performed ChIP-seq analyses for WT, H3K9M mutant and clr4 mutant in Schizosaccharomyces pombe, and showed that H3K9me3 level was reduced to background levels across the entire genome, similar to clr4 mutant.
ORGANISM(S): Schizosaccharomyces pombe 
2016-10-03 | E-MTAB-4776 | biostudies-arrayexpress
TranscriptomicsWhole Exome Sequencing of two non-obstructive azoospermia patients
We collected blood samples of two non-obstructive azoospermia patients, and performed whole exome sequencing to explore the causal mutations for male infertility.
ORGANISM(S): Homo sapiens 
2021-06-22 | E-MTAB-9287 | biostudies-arrayexpress
TranscriptomicsMelanoma short-term cultures and cell lines: expression profiling and CNV analyses
This SuperSeries is composed of the following subset Series: GSE17349: Expression data for melanoma short-term cultures and cell lines GSE17359: Affymetrix SNP array data for 3 melanoma short-term cultures and cell lines GSE20156: RNA-Seq of melanoma short-term cultures and cell lines Refer to indiv...
ORGANISM(S): Homo sapiens 
2010-02-01 | E-GEOD-17593 | biostudies-arrayexpress
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