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ProteomicsActinomycin targets NPM1c-primed mitochondria in AML
Acute myeloid leukemia (AML) pathogenesis often involves a mutation in the NPM1 nucleolar chaperone, but the bases for its transforming properties and association with favorable outcome remain incompletely understood. Here we demonstrate that an oncogenic mutant form of NPM1 (NPM1c) hampers formatio...
ORGANISM(S): Homo sapiens (Human) 
2021-12-17 | PXD025507 | Pride
Pml Lfq Actinomycin d Mitochondria Npm1c Qexactive Senescence 
UnknownSex- and estrous-cycle dependent dorsal hippocampal phosphoproteomic changes induced by low-dose ketamine.
Not available
S-EPMC8810966 | biostudies-literature
UnknownArabinogalactan protein 31 (AGP31), a putative network-forming protein in Arabidopsis thaliana cell walls?
Not available
S-EPMC4195544 | biostudies-literature
UnknownOncogenic KIT mutations induce STAT3-dependent autophagy to support cell proliferation in acute myeloid leukemia.
Not available
S-EPMC6635375 | biostudies-literature
TranscriptomicsIsocitrate dehydrogenase 1 mutations prime the all-trans-retinoic acid myeloid differentiation pathway in acute myeloid leukemia HL-60 cells
Human acute myeloid leukemia HL60 cells were transduced with IDH1-WT or IDH1-R132H, and corresponding sub-clones were generated by FACS. In a first series of experiments, cells expressing wt and mutant IDH1were treated with either 1µM all-trans retinoic acid (ATRA) or with vehicle (DMSO) for 24 hrs...
ORGANISM(S): Homo sapiens 
2017-03-01 | E-MTAB-4327 | biostudies-arrayexpress
UnknownThe nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness.
Not available
S-EPMC3173219 | biostudies-literature
ProteomicsInteractomic analysis of PEAK3 pseudo-kinase
The aim of the project was to identify the interactome of PEAK3 pseudokinase that was expressed in various cancer cells.
ORGANISM(S): Homo sapiens (Human) 
2022-01-04 | PXD029417 | Pride
Adhesive protein Pseudo-kinase Oncogene Signalling protein 
UnknownOncogenic FLT3-ITD supports autophagy via ATF4 in acute myeloid leukemia.
Not available
S-EPMC5808073 | biostudies-literature
UnknownMetformin inhibits growth of human glioblastoma cells and enhances therapeutic response.
Not available
S-EPMC4395104 | biostudies-literature
UnknownSuccessful split liver-kidney transplant for factor H associated hemolytic uremic syndrome.
Not available
S-EPMC2615708 | biostudies-literature
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