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GenomicsHistone variant, H2B.Z demarcates the AT-rich promoter regions of the Plasmodium falciparum genome
Histone variants are key components of the epigenetic code and evolved to perform specific functions in transcriptional regulation, DNA repair, chromosome segregation and other fundamental processes. H2B.Z is a rare, apicomplexan-specific variant of histone H2B. Here we show that in Plasmodium falci...
ORGANISM(S): Plasmodium falciparum 3D7 
2013-03-05 | E-GEOD-39702 | biostudies-arrayexpress
TranscriptomicsTranscription profile of the Plasmodium falciparum intraerythrocytic cycle
This experiment characterizes the transcriptome of the human malaria parasite, P. falciparum at 8 different stages of the intraerythrocytic cycle Examination of polyA selected RNA in Plasmodium falciparum 3D7 strain at 8 different stages using RNA-seq
ORGANISM(S): Plasmodium falciparum 3D7 
2010-10-28 | E-GEOD-23865 | biostudies-arrayexpress
TranscriptomicsP. falciparum Heterochromatin Protein 1 Marks Genomic Loci Linked to Phenotypic Variation of Exported Virulence Factors
Epigenetic processes are the main conductors of phenotypic variation in eukaryotes. The malaria parasite Plasmodium falciparum employs antigenic variation of the major surface antigen PfEMP1, encoded by 60 var genes, to evade acquired immune responses. PfEMP1 also mediates sequestration of infected ...
ORGANISM(S): Plasmodium falciparum 
2010-05-06 | E-GEOD-17029 | biostudies-arrayexpress
TranscriptomicsRepresentative Illumina sequencing libraries upon T7-polymerase based amplification
This experiment highlights the extreme sequence bias generated by standard PCR amplication of sequencing libraries and decribes an adapted T7-polymerase based amplification method, which results in non-baised, representative libraries for Illumina sequencing Adaptation of standard Illumina sequencin...
ORGANISM(S): Plasmodium falciparum 3D7 
2010-10-28 | E-GEOD-23868 | biostudies-arrayexpress
GenomicsEpigenetic profile of the Plasmodium falciparum intraerythrocytic cycle
This experiment characterizes the localisation of H2A.Z, H3K9ac and H3K4me3 in the epigenome of the human malaria parasite, P. falciparum at 4 different stages of intraerythrocytic development. Examination of H2A.Z, H3K9ac, H3K4me3 and mono-nucleosomal input in 3D7 strain at 4 different stages and H...
ORGANISM(S): Plasmodium falciparum 3D7 
2010-10-28 | E-GEOD-23867 | biostudies-arrayexpress
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