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ProteomicsDeep learning neural network prediction method improves proteome profiling of vascular sap of grapevines during Pierces disease development
Plant secretome studies have shown the importance of plant defense proteins in the vascular system against pathogens. Studies on Pierces disease of grapevines caused by the xylem-limited bacteria Xylella fastidiosa Xf have detected proteins and pathways associated to its pathobiology. Despite the bi...
ORGANISM(S): Vitis Vinifera (ncbitaxon:29760) Xylella Fastidiosa Temecula1 (ncbitaxon:183190) 
2020-08-12 | MSV000085942 | MassIVE
ProteomicsOmega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice
Soybean oil consumption is increasing worldwide and parallels the rise in obesity. Rich in unsaturated fats, especially linoleic acid, soybean oil is assumed to be healthy, and yet it induces obesity, diabetes, insulin resistance and fatty liver in mice. Here, we show that the genetically modified s...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-06-08 | MSV000081149 | MassIVE
ProteomicsElucidation of Familial Relationships Using Hair Shaft Proteomics
This study examines the potential of hair shaft proteomic analysis to delineate genetic relatedness. Proteomic profiling and amino acid sequence analysis provide information for quantitative and statistically based analysis of individualization and sample similarity. Protein expression levels are a ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-06 | MSV000086665 | MassIVE
ProteomicsHuman corneocyte cross-linked envelopes are comprised of a multitude of proteins
The cornified outer layer of epidermis (stratum corneum) is our major extra-pulmonary barrier to the environment. This layer results from a well-orchestrated program of terminal differentiation producing corneocytes filled primarily with keratin intermediate filaments tightly connected by disulfide ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-12-19 | MSV000083265 | MassIVE
ProteomicsEnvironmental pro-oxidants induce altered envelope protein profiles in human keratinocytes
Cornified envelopes (CEs) of human epidermis consist of transglutaminase-mediated cross-linked proteins and are essential for skin barrier function. Present work explores the influences of pro-oxidant pollutants on the CE protein profiles. In this study, we performed proteomic analysis on CEs induce...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-14 | MSV000090901 | MassIVE
ProteomicsAtg8ylation coordinates stress granule formation and mTOR inactivation in response to lysosomal damage
Stress granule formation is a part of cellular homeostatic responses, with prototypical inducers being viral infections, heat shock and oxidative damage. Here we show that lysosomal damage is a previously unappreciated robust inducer of stress granule formation interlinked with mTOR inactivation dur...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000088152 | MassIVE
ProteomicsMembrane atg8ylation coordinates stress granule formation and mTOR inactivation in response to lysosomal damage
We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG) formation and that the process termed membrane atg8ylation coordinates SG formation with mTOR inactivation during lysosomal stress. SGs were induced by lysosome-damaging agents including SARS-CoV-2ORF3a, Mycobacteri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-09 | MSV000089622 | MassIVE
ProteomicsAlternative LC-MS/MS Platforms and Data Acquisition Strategies for Proteomic Genotyping
Protein is a major component of all biological evidence. Proteomic genotyping is the use of genetically variant peptides that contain single amino acid polymorphisms to infer the genotype of matching non-synonymous single nucleotide polymorphisms for the individual who originated the protein sample....
ORGANISM(S): Homo Sapiens 
2021-09-10 | PXD024651 | panorama
ProteomicsATG9A is a component of the ESCRT system and governs plasma membrane repair
ATG9 is often described as the sole transmembrane protein among the core autophagy factors. The mammalian ATG9A is notorious for trafficking through numerous cellular compartments including the plasma membrane. The reasons for ATG9As wide intracellular distribution and its role at the PM are not ful...
ORGANISM(S): Homo 
2019-10-30 | MSV000084519 | MassIVE
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