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MetabolomicsBiomarker Discovery in Oral Cancer (OSMF & OSCC) and its severity

Oral squamous cell carcinoma (OSCC) is frequently the outcome of oral submucous fibrosis (OSMF), a common possibly premalignant disease. In our study, a cohort of 50 patients with OSCC and OSMF, along with 50 healthy controls, was analyzed to identify significant metabolic differences between the...

2024-10-23 | MTBLS11009 | MetaboLights
MetabolomicsExploring Salivary Metabolites as Biomarkers in Chronic Craniofacial and Orofacial Pain: A Metabolomic Analysis.
Chronic facial pain (CFP) includes a range of conditions such as musculoskeletal, neurovascular, and neuropathic disorders affecting the facial and jaw regions, often causing significant distress to patients. This study aims to investigate the metabolomic profile of patients with CFP, focusing on sa...
2025-07-16 | MTBLS12704 | MetaboLights
MetabolomicsIdentification of Salivary Lipid Biomarkers for Noninvasive Diagnosis of Reflux Esophagitis via UHPLC-MS-based Lipidomics
Introduction Reflux esophagitis (RE) is a common upper gastrointestinal disorder, and its diagnosis currently relies primarily on invasive endoscopic examination. The lack of reliable non-invasive biomarkers substantially limits early detection and large-scale screening. Saliva represents a promisin...
2026-03-31 | MTBLS14198 | MetaboLights
TranscriptomicsDevelopment of Transcriptomic Biomarker Signature in Human Saliva to Detect Lung Cancer
Affymetrix HG U133 Plus 2.0 Array (Affymetrix, Santa Clara, CA) was used to profile transcriptomes and discover altered gene expression in saliva supernatant. Salivary transcriptomic biomarker discovery was performed on 10 lung cancer patients and 10 matched controls. Seven messenger RNA biomarkers ...
ORGANISM(S): Homo sapiens 
2013-01-11 | E-GEOD-32175 | biostudies-arrayexpress
ProteomicsProteomics of saliva, plasma, and salivary gland tissue in Sjögren’s syndrome and non-Sjögren patients identify novel biomarker candidates
Objective: The aim of this study was to characterize and compare the proteome in whole saliva, plasma, and salivary gland tissue in patients with primary Sjögren’s syndrome (pSS) and patients having symptoms of pSS, but not fulfilling the classification criteria, and to search for diagnostic biomark...
ORGANISM(S): Homo sapiens (Human) 
2020-07-09 | PXD016231 | Pride
Saliva Plasma Sjögren’s syndrome Proteomics Biomarker Minor salivary glands 
TranscriptomicsMultiple Salivary Biomarkers for Early Detection of Pancreatic Cancer
Pancreatic cancer is the fourth leading cause of cancer death. Lack of early detection technology for pancreatic cancer invariably leads to a typical clinical presentation of incurable disease at initial diagnosis. Oral fluid (saliva) meets the demand for non-invasive, accessible, and highly efficie...
ORGANISM(S): Homo sapiens 
2008-12-30 | E-GEOD-14245 | biostudies-arrayexpress
TranscriptomicsSalivary microRNAs May Be A Valuable Biomarker To Detect Resectable Pancreatic Cancer
Early surgery is vital in the treatment of highly fatal pancreatic cancer (PC). But there is no valuable and non-invasive biomarker to screen PC currently. Studies showed many salivary molecules can detect several systemic diseases. We aimed to investigate whether salivary microRNAs (miRNAs) can act...
ORGANISM(S): Homo sapiens 
2013-12-15 | E-GEOD-53325 | biostudies-arrayexpress
ProteomicsSalivary orosomucoid 1 as a biomarker of hepatitis B associated hepatocellular carcinoma
Saliva is rich in proteins, DNA, RNA and microorganisms, and can be regarded as a biomarker library. In order to explore a noninvasive and simple means of early screening for liver cancer, proteomics was used to screen salivary markers of hepatitis B associated liver cancer. We used mass spectrometr...
ORGANISM(S): Homo sapiens (Human) 
2022-07-13 | PXD033752 | Pride
Salivary Orosomucoid 1 Hepatocellular carcinoma Α-fetoprotein Biomarkers 
TranscriptomicsSalivary Transcriptomic and Proteomic Biomarkers for Breast Cancer Detection
A sensitive assay to identify biomarkers that can accurately diagnose the onset of breast cancer using non-invasively collected clinical specimens is ideal for early detection. In this study, we have conducted a prospective sample collection and retrospective blinded validation (PRoBE design) to eva...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-20266 | biostudies-arrayexpress
ProteomicsDevelopment of a potential salivary biomarker panel for Oral Squamous Cell Carcinoma using a proteomics-based approach.
Oral Squamous Cell Carcinoma (OSCC) is one of the most prevalent cancers in the world with the maximum number of cases reported from India. Poor survival rate associated with OSCC can be attributed to the non-availability of a biomarker, as one of the major reasons, leading to late presentation. Ide...
ORGANISM(S): Homo Sapiens 
2021-07-09 | PXD020263 | panorama
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