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ProteomicsQuantitative Analysis of Differential Proteomes in Mouse Mesenchymal Stem Cells Converted to Salivary Epithelial Precursors
Severe hyposalivation often results from Sjögren’s syndrome or radiation therapy for head and neck cancer. Devastating consequences of hyposalivation, such as rampant dental caries and persistent oral candidiasis, compromise the quality of life in those patients. Clinical management for dry mouth ty...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-14 | PXD002796 | Pride
Proteomics Dry mouth Salivary epithelial precursors Co-culture Transcription factors Bone marrow-derived mesenchymal stem cells Itraq Salivary gland regeneration 
GenomicsSingle-cell RNAseq analysis of murine salivary gland development
Single-cell RNAseq analysis of murine salivary gland development
PRJNA631774 | ENA
TranscriptomicsIdentification of the hypothalamic neuronal populations that derive from Pomc-expressing precursors
Hypothalamic neuronal populations are central regulators of energy homeostasis and reproductive function. However, the ontogeny of these critical hypothalamic neuronal populations is largely unknown. Here, we reveal novel cellular fates of the hypothalamic Pomc-expressing precursors by combining mou...
ORGANISM(S): Mus musculus 
2015-04-16 | E-GEOD-56917 | biostudies-arrayexpress
GenomicsCell Type Specific Enrichment Of Risk Associated Regulatory Elements At Ovarian Cancer Susceptibility Loci
Understanding the regulatory landscape of the human genome is a central question in complex trait genetics. Most single nucleotide polymorphisms (SNPs) associated with cancer risk lie in non protein-coding regions, implicating regulatory DNA elements as functional targets of susceptibility variants....
ORGANISM(S): Homo sapiens 
2015-04-22 | E-GEOD-68104 | biostudies-arrayexpress
TranscriptomicsTranscriptome dynamics of developing photoreceptors in 3-D retina cultures recapitulates temporal sequence of human cone and rod differentiation revealing cell surface markers and gene networks
To define molecular mechanisms underlying rod and cone differentiation, we generated H9 human embryonic stem cell line carrying a GFP reporter that is controlled by the promoter of cone-rod homeobox (CRX) gene, the first known marker of post-mitotic photoreceptor precursors. CRXp-GFP reporter in H9 ...
ORGANISM(S): Homo sapiens 
2015-08-03 | E-GEOD-67645 | biostudies-arrayexpress
TranscriptomicsNEUROMESO
Exposure of mouse ESCs to a sequence of extrinsic signals, which recapitulates in vivo development, generates a bipotential neuromesodermal precursor (NMP) that can be directed to differentiate into either spinal cord or paraxial mesodermal tissue. To induce differentiation,mouse ES cells were plate...
ORGANISM(S): Mus musculus 
2014-07-18 | E-MTAB-2268 | biostudies-arrayexpress
ProteomicsDeep Visual Proteomics defines single-cell identity and heterogeneity
Despite the availabilty of imaging-based and mass-spectrometry-based methods for spatial proteomics, a key challenge remains connecting images with single-cell-resolution protein abundance measurements. Here we introduce Deep Visual Proteomics (DVP), which combines artificial-intelligence-driven ima...
ORGANISM(S): Homo sapiens (Human) 
2022-04-27 | PXD023904 | Pride
Microscopy Digital pathology Proteomics Laser microdissection 
TranscriptomicsAll trans-retinoic acid (ATRA) effect on triple negative (TNBC) and luminal (LumA/LumB) primary breast tumors
We performed whole genome gene expression microarrays on short-term cultures of mammary tumors deriving from diagnostic Tru-cut procedures of 16 patients in order to evaluate transcriptional response to the retinoid. Tissue slices were challenged with vehicle (DMSO) or ATRA 0.1åµm for 48 hours. The ...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-MTAB-3313 | biostudies-arrayexpress
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