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ProteomicsFunctional Requirements for a Samd14-Capping Protein Complex in Stress Erythropoiesis
Acute anemia induces rapid expansion of erythroid precursors and accelerated differentiation to replenish erythrocytes. Paracrine signals – involving cooperation between SCF/c-Kit signaling and other signaling inputs – are required for the activation and function of erythroid precursors in anemia. O...
ORGANISM(S): Anemia Mus musculus (Mouse) 
2022-08-09 | PXD030467 | Pride
Samd14  capping protein  c-kit  erythropoietin  stress erythropoiesis 
ProteomicsMast cell-derived SAMD14 is a novel regulator of the human prostate tumor microenvironment
Mast cells (MCs) are important cellular components of the tumor microenvironment and are significantly associated with poor patient outcomes in prostate cancer and other solid cancers. The promotion of tumor progression partly involves heterotypic interactions between MCs and cancer-associated fibro...
ORGANISM(S): Homo sapiens (Human) 
2021-03-12 | PXD022782 | Pride
Prostate cancer  tumor microenvironment  mast cells  samd14  cancer-associated fibroblasts  extracellular matrix 
UnknownFunctional requirements for a Samd14-capping protein complex in stress erythropoiesis.
Not available
S-EPMC9282853 | biostudies-literature
UnknownGATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia.
Not available
S-EPMC5578808 | biostudies-literature
UnknownMast Cell-Derived SAMD14 Is a Novel Regulator of the Human Prostate Tumor Microenvironment.
Not available
S-EPMC7999778 | biostudies-literature
UnknownIntegration of the B-Cell Receptor Antigen Neurabin-I/SAMD14 Into an Antibody Format as New Therapeutic Approach for the Treatment of Primary CNS Lymphoma.
Not available
S-EPMC7689012 | biostudies-literature
Unknownlnc-SAMD14-4 can regulate expression of the COL1A1 and COL1A2 in human chondrocytes.
Not available
S-EPMC6727836 | biostudies-literature
ProteomicsA Phosphoinositide Interacting Protein Coordinates Stress Precursor Activities
Samd14 coordinates stem cell factor/Kit receptor signaling and is crucial for the survivalof red blood cel precursors within anemia contexts. Here we present new findings that Samd14 expression is needed to maintain balanced autophagy in red blood cell precursors following acute anemia. Autophagy ge...
ORGANISM(S): Anemia Mus musculus (Mouse) 
2026-02-11 | PXD067716 | Pride
Autophagy Samd14 Red blood cells Phosphatidylinositol 3-phosphate 
TranscriptomicsGene expression changes in control- and shSamd14-infected R1 fetal liver
Samd14 was discovered as a novel GATA-2 target gene. Samd14 increased hematopoietic progenitor levels/activity, promoted signaling by a pathway instrumental for hematopoietic stem/progenitor cell regulation (Stem Cell Factor/c-Kit), and c-Kit rescued Samd14 loss-of-function phenotypes
ORGANISM(S): Mus musculus 
2015-06-11 | GSE68602 | GEO
TranscriptomicsGene expression changes in control- and shSamd14-infected R1 fetal liver
Samd14 was discovered as a novel GATA-2 target gene. Samd14 increased hematopoietic progenitor levels/activity, promoted signaling by a pathway instrumental for hematopoietic stem/progenitor cell regulation (Stem Cell Factor/c-Kit), and c-Kit rescued Samd14 loss-of-function phenotypes A control sh...
ORGANISM(S): Mus musculus 
2015-06-11 | E-GEOD-68602 | biostudies-arrayexpress
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