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TranscriptomicsSAMHD1 restrains aberrant nucleotide insertions at repair junctions generated by DNA end joining
Aberrant end joining of DNA double strand breaks leads to chromosomal rearrangements and to insertion of nuclear or mitochondrial DNA into breakpoints, which is commonly observed in cancer cells and constitutes a major threat to genome integrity. However, the mechanisms that are causative for these ...
ORGANISM(S): Homo sapiens 
2021-01-20 | E-MTAB-8382 | biostudies-arrayexpress
ProteomicsGuanine-containing ssDNA and RNA induce dimeric and tetrameric SAMHD1 in cryo-EM and binding studies
The dNTPase activity of tetrameric SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) plays a critical role in cellular dNTP regulation. SAMHD1 also associates with stalled DNA replication forks, DNA repair foci, ssRNA, and telomeres. The above functions require...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2023-11-13 | PXD043587 | Pride
Aicardi-goutieres syndrome Dna repair Rnase Sammhd1 Hiv 
ProteomicsSAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA
Recognition of pathogen-derived foreign nucleic acids is central to innate immune defense. This requires discrimination between structurally highly similar self and nonself nucleic acids to avoid aberrant inflammatory responses as in the autoinflammatory disorder Aicardi-Goutires syndrome (AGS). How...
ORGANISM(S): Homo sapiens (Human) 
2023-02-06 | PXD035182 | Pride
Innate immunity Human Aicardi-goutires syndrome (ags) Samhd1 
TranscriptomicsSAMHD1 is a phospho-regulated Rnase that is essential for restricting HIV-1 infection through direct cleavage of HIV-1 genomic RNA
SAMHD1 restricts HIV-1 replication in dendritic and other myeloid cells. SAMHD1 has been shown to possess a dGTP-dependent dNTP triphosphatase (dNTPase) activity and is proposed to inhibit HIV-1 replication by depleting the intracellular dNTP pool. Arguing against a role for SAMHD1 dNTPase ...
ORGANISM(S): Homo sapiens 
2014-06-13 | E-GEOD-58418 | biostudies-arrayexpress
GenomicsGene expression of fibroblasts carrying SAMHD1 mutations or not
Gene expression of fibroblasts carrying SAMHD1 mutations or not
PRJNA559555 | ENA
ProteomicsTransformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1
Telomeres play crucial roles during tumorigenesis inducing cellular senescence upon telomere shortening and extensive chromosome instability during telomere crisis. However, it has not been investigated if and how cellular transformation and oncogenic stress alters telomeric chromatin composition an...
ORGANISM(S): Homo sapiens (Human) 
2018-07-13 | PXD010088 | Pride
Quantitative proteomics Telomeres Samhd1 Transformation Replication stress 
GenomicsSAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA
rRNA 2'-O-methylation SAMHD1
PRJEB54085 | ENA
GenomicsGene expression changes in different clones of SAMHD1 knock-out (KO) cells
Gene expression changes in different clones of SAMHD1 knock-out (KO) cells
PRJNA889742 | ENA
ProteomicsSAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks
Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) has a dNTPase-independent function in promoting DNA end resection to facilitate DNA double-strand break (DSB) repair by homologous recombination (HR); however, it is not known if upstream signaling events govern this activity. Here, we ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031357 | Pride
Acetylation Ipms 
GenomicsMicroarray analysis in acute myeloid leukemia (AML)-derived THP-1 cells expressing or not SAMHD1
Microarray analysis in acute myeloid leukemia (AML)-derived THP-1 cells expressing or not SAMHD1
PRJNA453392 | ENA
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