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UnknownA taxogenomic view of the genus <i>Torulaspora</i>: an expansion from ten to twenty-two species.
The yeast genus Torulaspora (subphylum Saccharomycotina, family Saccharomycetaceae) is mostly known from its type species, T. delbrueckii, a frequent colonizer of wine and sourdough bread fermentations. The genus currently contains 10 species that are typically found in v...
S-EPMC12308288 | biostudies-literature
MetabolomicsUntargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase

INTRODUCTION: Interesting data about the family Asteraceae as a new source of Leishmania major dihydroorotate dehydrogenase (LmDHODH) inhibitors are presented. This key macromolecular target for parasites causing neglected diseases catalyzes the fourth reaction of the de novo pyr...

2019-10-14 | MTBLS722 | MetaboLights
MetabolomicsUncovering the Complexity of the Yeast Lipidome by Means of nLC/NSI-MS/MS
Saccharomyces cerevisiae is a eukaryotic model organism widely used for the investigation of fundamental cellular processes and disease mechanisms. Consequently, the lipid landscape of yeast has been extensively investigated and up to this day the lipidome is considered as rather basic. Here, we use...
2021-01-08 | MTBLS2119 | MetaboLights
ProteomicsQuantitative proteomics upon Fentomycin treatment VS untreated in human fibrosarcoma HT1080 cells
Our data of mass spectrometry-based lipidomics showed that fentomycin induced the oxidation of membrane lipids in HT-1080 cells compared with the established ferroptosis inducers. To deepen this discovery, we performed quantitative mass spectrometry-based proteomics using the sublethal dose of fento...
ORGANISM(S): Homo sapiens (Human) 
2025-03-06 | PXD054449 | Pride
Fentomycin Proteome Fibrosarcoma Ferroptosis 
UnknownShotgun mass spectrometry-based lipid profiling identifies and distinguishes between chronic inflammatory diseases.

Background

Localized stress and cell death in chronic inflammatory diseases may release tissue-specific lipids into the circulation causing the blood plasma lipidome to reflect the type of inflammation. However, deep lipid profiles of major chronic inflammatory diseases have not been compare...
S-EPMC8330692 | biostudies-literature
MetabolomicsInositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
Vesicular traffic and membrane contact sites between organelles enable the exchange of proteins, lipids, and metabolites. Recruitment of membrane tethers to contact sites between the endoplasmic reticulum (ER) and the plasma membrane is often triggered by calcium. In contrast, we reveal here a funct...
2021-05-06 | MTBLS2444 | MetaboLights
UnknownPreexposure chemoprophylaxis for HIV prevention in men who have sex with men.

Background

Antiretroviral chemoprophylaxis before exposure is a promising approach for the prevention of human immunodeficiency virus (HIV) acquisition.

Methods

We randomly assigned 2499 HIV-seronegative men or transgender women who have sex with men to receive a combination of two or...
S-EPMC3079639 | biostudies-literature
UnknownRepurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype.
Batten diseases (BDs) are a group of lysosomal storage disorders characterized by seizure, visual loss, and cognitive and motor deterioration. We discovered increased levels of globotriaosylceramide (Gb3) in cellular and murine models of CLN3 and CLN7 diseases and used fluorescent-conjugated bacteri...
S-EPMC8495452 | biostudies-literature
UnknownActivation of lysosomal iron triggers ferroptosis in cancer.
Iron catalyses the oxidation of lipids in biological membranes and promotes a form of cell death called ferroptosis1. Defining where this chemistry occurs in the cell can inform the design of drugs capable of inducing or inhibiting ferroptosis in various disease-relevant settings. Genetic...
S-EPMC12158755 | biostudies-literature
UnknownRandomized Trial of BCG Vaccine to Protect against Covid-19 in Health Care Workers.

Background

The bacille Calmette-Guérin (BCG) vaccine has immunomodulatory "off-target" effects that have been hypothesized to protect against coronavirus disease 2019 (Covid-19).

Methods

In this international, double-blind, placebo-controlled trial, we randomly assigned health care wo...
S-EPMC10497190 | biostudies-literature
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