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TranscriptomicsRNA-seq of different tissues from wild-type and C/EBPα ΔuORF mutant African turquoise killifish Nothobranchius furzeri
The transcription factor CCAAT/enhancer binding protein alpha (C/EBPα) regulates cell differentiation, proliferation, and function in various tissues, including the liver, adipose tissue, skin, lung, and hematopoietic system. Studies in rats, mice, humans, and chickens have shown that CEBPA mRNA und...
ORGANISM(S): Nothobranchius furzeri 
2026-05-26 | E-MTAB-15325 | biostudies-arrayexpress
TranscriptomicsPBMC response to B. pertussis filamentous hemagglutinin stimulation in vitro
Filamentous hemagglutinin (FHA), Bordetella pertussis' key adhesin, is both present at the cell surface and released in the extracellular milieu. To comprehend the role free FHA plays in the pathogenic process, we analyzed the global transcriptional changes in human peripheral blood mononuclear cell...
ORGANISM(S): Homo sapiens 
2008-10-29 | E-GEOD-8802 | biostudies-arrayexpress
ProteomicsProteomic profiling of Palbociclib arrested cells ± APC/C inactivation.
Cellular proliferation is highly regulated to ensure proper tissue homeostasis and to prevent diseases such as cancer. In actively proliferating cells, entry into S phase of the cell cycle and initiation of DNA replication is promoted by inactivation of the E3 ubiquitin ligase APC/C (anaphase promot...
ORGANISM(S): Homo sapiens (Human) 
2024-07-18 | PXD046783 | Pride
Cancer Palbociclib Cell cycle Apc/c 
TranscriptomicsDifferential production of Type I IFN determines the reciprocal levels of IL-10 and proinflammatory cytokines produced by C57BL/6 and BALB/c macrophages
Pattern recognition receptors (PRR) detect microbial products and induce cytokines which shape the immunological response. Interleukin-12 (IL-12), tumor necrosis factor alpha (TNF-α) and IL-1β are proinflammatory cytokines which can be essential for resistance against infection, but if produced at...
ORGANISM(S): Mus musculus 
2016-09-07 | E-GEOD-79809 | biostudies-arrayexpress
TranscriptomicsResponse of Rhodopirellula baltica to heat shock
Expression profiling of the stress response of the marine Planctomycete Rhodopirellula baltica after a temperature up-shift. R. baltica cultures were grown at 28°C and then shifted to 37°C. Samples were taken after 10, 20, 40, 60 and 300min and compared with cultures before the up-shift (28°C). Tim...
ORGANISM(S): Rhodopirellula baltica 
2009-09-09 | E-GEOD-13769 | biostudies-arrayexpress
ProteomicsOptimized sample preparation, data processing of data-independent acquisition methods for the robust quantification of trace-level host cell protein impurities in drug products
In this study, we developed powerful and reproducible MS-based analytical workflows coupling optimized and efficient sample preparations, library-free DIA acquisition method and stringent validation criteria. The performances of several preparation protocols and DIA versus classical DDA were evaluat...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2020-10-19 | PXD019668 | Pride
Host cell proteins (hcp) Quantification Data-independent analysis (dia) Mass spectrometry Sample preparation 
ProteomicsReticular fibroblasts counteract radiotherapy-induced head and neck tumor regression through Tenascin-C
Head and neck squamous cell carcinoma (HNSCC) patients have a very short survival. To improve patient survival, there is an emerging need for a better understanding of the obstacles of ionizing irradiation (IR), besides surgery, currently the best treatment option for HNSCC. A confounding factor is ...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-14 | PXD060164 | Pride
Tenascin-c Radiotherapy Reticular fibroblasts Tumor 
TranscriptomicsTranscription profiling and QTL mapping of 60 mice from an F2 sample segregating for diabetes to generate expression trait correlations and expression quantitative trait locus mapping.
Coordinated regulation of gene expression levels across a series of experimental conditions provides valuable information about the functions of correlated transcripts. To map gene regulatory pathways, we used microarray-derived gene expression measurements in 60 individuals of an F2 sample segregat...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3330 | biostudies-arrayexpress
ProteomicsTenascin-C shapes TRAIL control over tumor immunity
TRAIL cytotoxicity is exploited as anti-cancer therapy since many years, however incomplete knowledge is generating many obstacles. Here, we address whether the highly abundant extracellular matrix molecule tenascin-C (TNC) orchestrating an immune suppressive tumor microenvironment and binding TRAIL...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-15 | PXD045388 | Pride
Shotgun proteomics Tenascin c Trail Maremo peptide mp5 
TranscriptomicsTranscription profiling of human squamous cell carcinoma of the head and neck cells reveals tumor growth and prognosis of squamous cell carcinoma of the head and neck is linked to protein kinase C alpha
Protein Kinase C alpha (PKC) is a critical mediator of cell signaling and cancer growth. We show that PKC inhibitors decrease proliferation in squamous cell carcinoma of the head and neck (SCCHN) cells and abrogate growth of SCCHN tumors in mouse xenografts. Analysis of gene expression arrays reveal...
ORGANISM(S): Homo sapiens 
2009-03-28 | E-GEOD-10299 | biostudies-arrayexpress
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