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Proteomics,MultiomicsCyclin C-CDK3/8/19 kinases play a tumor-suppressive role in vivo
Cyclin C was cloned as a growth-promoting G1 cyclin1,2, and several studies postulated a role for cyclin C in driving cell proliferation3-8 . Moreover, cyclin C, together with its kinase partner, the cyclin-dependent kinase CDK8, is believed to represent an essential component of basal transcrip...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080728 | MassIVE
TranscriptomicsmRNA expression data of 62 human medulloblastoma tumors
To identify molecular subtypes of medulloblastoma we have profiled a series of 62 medulloblastoma tumors. Unsupervised hierarchical cluster analysis of these data identified 5 distinct molecular subtypes. Manuscript submitted. Title: Identification of medulloblastoma subtypes with distinct genetic p...
ORGANISM(S): Homo sapiens 
2008-09-02 | E-GEOD-10327 | biostudies-arrayexpress
TranscriptomicsCyclin C-CDK3/8/19 kinases play a tumor-suppressive role in vivo
Cyclin C was cloned as a growth-promoting G1 cyclin, and several studies postulated a role for cyclin C in driving cell proliferation. Moreover, cyclin C, together with its kinase partner, the cyclin-dependent kinase CDK8, is believed to represent an essential component of basal transcriptional ...
ORGANISM(S): Mus musculus 
2014-09-02 | E-GEOD-58712 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human paediatric medulloblastoma samples and normal cerebellum to investigate the occurance of alternative splicing
Alternative pre-mRNA splicing critically contributes to the generation of protein variety in a tissue- and development-specific manner. Alterations in the normal pathways of alternative splicing (AS) have been associated with the growth and maintenance of several tumour types, and have been indicate...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-MTAB-292 | biostudies-arrayexpress
ProteomicsImproved reversed phase chromatography of hydrophilic peptides from spatial and temporal changes in column temperature
Reversed phase chromatography is an established method for peptide separation and frequently coupled to electrospray ionization-mass spectrometry for proteomic analysis. Column temperature is one parameter that influences peptide retention and elution, but it is often overlooked as its implementatio...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2017-04-10 | PXD006112 | Pride
Liquid chromatography Bsa Hydrophilic peptide Mass spectrometry Temperature Hela Isoaspartic acid 
TranscriptomicsMethylation data from presentation and relapsed medulloblastoma tumour samples
We undertook a comprehensive clinical and biological investigation of serial medulloblastoma biopsies obtained at diagnosis and relapse. Combined MYC gene family amplifications and P53 pathway defects commonly emerged at relapse, and all patients in this molecular group died of rapidly progressive d...
ORGANISM(S): Homo sapiens 
2015-04-23 | E-GEOD-62618 | biostudies-arrayexpress
TranscriptomicsAnalysis of genomic instability in esophageal squamous cell carcinoma (ESCC)
To characterize genomic instability in esophageal squamous cell carcinoma, we examined loss of heterozygosity, copy number loss, and copy number gain in ESCC patients from a high-risk region of China. Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted fr...
ORGANISM(S): Homo sapiens 
2010-04-10 | E-GEOD-15526 | biostudies-arrayexpress
UnknownDevelopment of temperament types from infancy to adolescence: Genetic and environmental influences with an economically and racially/ethnically diverse sample.
Not available
S-EPMC11866458 | biostudies-literature
UnknownAbsence of neurocognitive effect of hepatitis C infection in HIV-coinfected people.
Not available
S-EPMC4335996 | biostudies-literature
UnknownPredictors of contact with services for mental health problems among children with comorbid long-term physical health conditions: a follow-up study.
Not available
S-EPMC10807016 | biostudies-literature
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