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ProteomicsSelective activation of PERK signaling mediates fibroblast education and tumor progression by a CRELD2-dependent mechanism
It is now well-accepted that cancers co-opt the microenvironment to support their growth. However, the molecular mechanisms underlying cancer-microenvironment interactions remain poorly defined. We have found that Rho-associated kinase (ROCK) activity in the epithelial component of mammary tumors se...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-27 | PXD018253 | Pride
Cancer progression Integrated stress response (isr) Unfolded protein response 25 (upr) Perk Cancer-associated fibroblasts (cafs) Breast cancer Endoplasmic reticulum (er)stress Rock 26 extracellular matrix Tumor microenvironment 
UnknownEvaluating Cancer of the Central Nervous System Through Next-Generation Sequencing of Cerebrospinal Fluid.
Not available
S-EPMC4981784 | biostudies-literature
TranscriptomicsExpression data from Versican (VCAN) protein treated ovarian cancer cell line OVCA433
Advanced ovarian cancer is the most lethal gynecologic malignancy in the United States. Currently patients are treated by surgical cytoreductive surgery with the aim of reducing tumor burden to microscopic disease followed by adjuvant combined treatment with a platinum and taxane containing chemothe...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-40241 | biostudies-arrayexpress
UnknownPhase II trial of cetuximab with or without paclitaxel in patients with advanced urothelial tract carcinoma.
Not available
S-EPMC3454772 | biostudies-literature
UnknownModification of the Creator recombination system for proteomics applications--improved expression by addition of splice sites.
Not available
S-EPMC1421398 | biostudies-literature
UnknownAlterations in DNA Damage Response and Repair Genes as Potential Marker of Clinical Benefit From PD-1/PD-L1 Blockade in Advanced Urothelial Cancers.
Not available
S-EPMC6366295 | biostudies-literature
UnknownGenome-Wide DNA Methylation Analysis Reveals Epigenetic Dysregulation of MicroRNA-34A in TP53-Associated Cancer Susceptibility.
Not available
S-EPMC6366343 | biostudies-literature
TranscriptomicsCooler temperatures destabilize RNA interference and increase susceptibility of disease vector mosquitoes to viral infection
The impact of global climate change on the transmission dynamics of infectious diseases is the subject of extensive debate. The transmission of mosquito-borne viral diseases is particularly complex, with climatic variables directly affecting many parameters associated with the prevalence of disease ...
ORGANISM(S): Aedes albopictus 
2013-08-13 | E-GEOD-46204 | biostudies-arrayexpress
UnknownElectronic Trigger-Based Intervention to Reduce Delays in Diagnostic Evaluation for Cancer: A Cluster Randomized Controlled Trial.
Not available
S-EPMC4622097 | biostudies-literature
UnknownRas pathway inhibition prevents neovascularization by repressing endothelial cell sprouting.
Not available
S-EPMC3809796 | biostudies-literature
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