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TranscriptomicsIdentification of SOX4 novel transcriptional targets.
The SOX4 gene belongs to a family of transcription factors and we previously unveiled SOX4 gene amplification and over-expression in a subset of lung cancers, indicating it may constitute a driver oncogene. Here, we searched for SOX4 transcriptional targets and investigate their involvement in lung ...
ORGANISM(S): Homo sapiens 
2011-11-18 | E-GEOD-31612 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Lung H1299-BRG1 inducible cells
Global Transcriptional analysis of BRG1 in lung cancer cells Comparative transcriptional profile comparing the expression in lung cancer cells before and after restoring the wild type BRG1 or mutant BRG1 expression controlled by the Tet-ON system (doxycycline depending expression)
ORGANISM(S): Homo sapiens 
2012-03-12 | E-GEOD-35168 | biostudies-arrayexpress
TranscriptomicsGene amplification of the transcription factor DP1 and the CTNND1 in human lung cancer
The search for novel oncogenes is important because these could be the target of future specific anticancer therapies. In the present work, we report the identification of novel amplified genes in lung cancer. In order to find out novel amplified genes in lung cancer, we aligned the gene expression ...
ORGANISM(S): Homo sapiens 
2010-04-11 | E-GEOD-21168 | biostudies-arrayexpress
TranscriptomicsGene expression analysis & Comparative genomic hybridization from Lung cancer Cell lines
Gene expression and Comparative genomic hybridization (CGH) microarrays performed in a set of 8 Lung cancer Cell lines. The search for oncogenes is becoming increasingly important in cancer genetics because they constitute suitable targets for therapeutic intervention. To identify novel oncogenes, a...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-14079 | biostudies-arrayexpress
ProteomicsMAX-mutant small cell lung cancers exhibit impaired activities of MGA-dependent ncPRC1.6.
The MYC axis is commonly disrupted in cancer, mostly by activation of the MYC family of oncogenes, but also by genetic inactivation of MAX, the obligate partner of MYC, and of the MAX partner, MGA, both of which are members of the polycomb repressive complex, ncPRC1.6. While the oncogenic properties...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD017658 | Pride
Max-gene associated protein Proteomics Cell lung cancer Mga Immunoprecipitation Max 
TranscriptomicsIdentification of PARD3 signature on PARD3 deficient H157 cell line, reconstituting the expression of PARD3 gene, with a wt and a mutant form.
To development our gene expression approach, we have employed whole genome microarray expression profiling as a discovery platform to identify genes potentialy regulated by the polarity protein PAR3. Human SCC cell line, NCI-H157 (H157), has a big deletion at PARD3 locus and showed no PAR3 protein e...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-51506 | biostudies-arrayexpress
TranscriptomicsIdentification of MAX signature on MAX deficient SCLC cell lines
To development our gene expression approach, we have employed whole genome microarray expression profiling as a discovery platform to identify genes potentialy regulated by the transcription factor MAX.Human SCLC cell lines waere analyzed for mutations at the MAX locus. Those cell lines that were f...
ORGANISM(S): Homo sapiens 
2013-12-28 | E-GEOD-48559 | biostudies-arrayexpress
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