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ProteomicsSpecies identification of ancient Lithuanian fish remains using collagen fingerprinting
Morphological identification of ancient bone is often problematic due to heavy fragmentation that generally influences zooarchaeological assemblages. Fish bones are more taphonomically sensitive than those of other vertebrates as they are typically smaller and less biomineralised. Thus, taxonomic id...
ORGANISM(S): Salmo trutta fario Scophthalmus maximus Sander lucioperca Scophthalmus rhombus Salmo trutta trutta Gadus morhua (Atlantic cod) Esox lucius Salmo salar (Atlantic salmon) Silurus glanis Carassius carassius 
2018-08-29 | PXD010041 | Pride
Zooarchaeology Zooms Ichthyoarchaeology Species identification Neolithic Collagen fingerprinting Fish bone 
ProteomicsTemporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19
Using omics tools with the SARS-CoV-2 infected Syrian hamster as model for COVID-19, along with published datasets from COVID-19 patients, Nouailles et al. present a detailed longitudinal analysis of systemic and pulmonary quantitative and qualitative immune responses in a moderate disease setting. ...
ORGANISM(S): Mesocricetus auratus (Golden hamster) 
2021-06-17 | PXD025164 | Pride
Mesocricetus auratus Sars-cov-2 
TranscriptomicsTranscription profiling of human and mouse hepatocytes to perform a comparative analysis of gene regulation by the transcription factor PPARI?_mouse
Studies in mice have shown that PPARα is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARα in human liver. Here we set out to compare the function of PPARα in mouse and human hepatocytes via analysis of t...
ORGANISM(S): Mus musculus 
2009-09-25 | E-GEOD-17250 | biostudies-arrayexpress
TranscriptomicsSensing prokaryotic mRNA signifies microbial viability and promotes immunity
MyD88-independent signal transduction associated with Toll-like receptors (TLRs) 3 and TLR4 is mediated through the adapter protein TRIF (TIR-domain-containing adapter-inducing interferon-beta). It has been proposed that TLR signalling is important for the transcription of crucial inflammasome compo...
ORGANISM(S): Mus musculus 
2011-05-22 | E-GEOD-27960 | biostudies-arrayexpress
TranscriptomicsDetailed transcriptomics analysis of the effect of the PPARalpha agonist Wy14,643 on gene regulation in the murine heart
Fatty acids comprise the primary energy source for the heart and are mainly taken up via hydrolysis of circulating triglyceride-rich lipoproteins. While most of the fatty acids entering the cardiomyocyte are oxidized, a small portion is involved in altering gene transcription to modulate cardiometab...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-30553 | biostudies-arrayexpress
TranscriptomicsEpigenomic landscapes of human inflammation associated macrophages [RNA-seq]
We previously demonstrated by genomic and bioinformatical approaches that human macrophage (MΦ) activation is best described by a spectrum model (Xue et al, Immunity, 2014). MΦ integrate exogenous input signals on transcriptional level in a unique fashion to generate specific functional programs, ...
ORGANISM(S): Homo sapiens 
2016-02-28 | E-GEOD-66593 | biostudies-arrayexpress
TranscriptomicsHepatic acute phase proteins control innate immune responses during infection by promoting myeloid derived suppressor cell function
Acute phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation. Despite vast pro- and anti-inflammatory properties ascribed to individual APPs, their collective function during infections remains poorly defined. U...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-22009 | biostudies-arrayexpress
UnknownThe direct healthcare costs attributable to West Nile virus illness in Ontario, Canada: a population-based cohort study using laboratory and health administrative data.
Not available
S-EPMC6918579 | biostudies-literature
TranscriptomicsTranscription profiling of human and moise primary hepatocytes from 12 donors were treated with PPARI? agonist Wy14643
Studies in mice have shown that PPARα is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARα in human liver. Here we set out to compare the function of PPARα in mouse and human hepatocytes via analysis of t...
ORGANISM(S): Mus musculus 
2009-09-11 | E-GEOD-17254 | biostudies-arrayexpress
ProteomicsThe human host response to monkeypox infection: a proteomic case series study
The rapid rise of Monkeypox (MPX) cases outside previously endemic areas prompt for a better understanding of the disease. We studied the plasma proteome of a group of MPX patients with a similar infection history and clinical manifestation typical for the current outbreak. We report that MPX is ass...
ORGANISM(S): Homo sapiens (Human) 
2022-09-22 | PXD036074 | Pride
Proteomics Viral infection Host response Monkeypox virus Zeno swath 
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