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TranscriptomicsTranscription profiling of different types of skeletal muscles from wild type and alpha tropomyosin transgenic slow mice to investigate the molecular mechanisms implicated in the mouse model of nemaline myopathy.
The aim of this study was to investigate the molecular mechanisms implicated in this mouse model of nemaline myopathy, and to further compare the molecular disease response in different skeletal muscles. For this purpose, snap frozen skeletla muscle specimens from wild type and transgenic for alpha ...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-3384 | biostudies-arrayexpress
TranscriptomicsMolecular profiles(HG-U95B,C,D,E) of dystrophin-deficient and normal human skeletal muscle
molecular profiles (HG-U95B,C,D,E) of biopsy skeletal muscle samples obtained from 10 normal individuals and 10 DMD patients Keywords = gene expression profiles of normal human skeletal muscles Keywords = gene expression profiles of DMD patients' skelatal muscle samples Keywords = Affymetrix HG-U95B...
ORGANISM(S): Homo sapiens 
2004-02-04 | E-GEOD-1007 | biostudies-arrayexpress
TranscriptomicsTransgenic mice carrying the human PLN gene
These mice have been genetically modified so that the mouse PLN gene has been replace with the human PLN gene. Phopspholamban (PLN), the reversible inhibitor of the sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a), is a key regulator of myocyte Ca2+-cycling with a significant role in heart failure....
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-20172 | biostudies-arrayexpress
TranscriptomicsMolecular profiles (HG-U95A) of dystrophin-deficient and normal human muscle
Molecular profiles of dystophin-deficient patients and normal human skeletal muscles on Affymetrix HG-U95A arrays Keywords = DMD Keywords = Duchenne muscular dystrophy Keywords = dystrophin Keywords = Affymetrix U95A array Keywords = skeletal muscle Keywords = gene expression profiles Keywords: othe...
ORGANISM(S): Homo sapiens 
2004-01-29 | E-GEOD-1004 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C2C12 myoblasts induced to differentiate in vitro over a 12 day time series to identify novel genes involved in myogenic differentiation.
In this study, Affymetrix MG_U74Av2 and MG_U74Cv2 GeneChips were used to analyze gene expression over a 12 day time course in C2C12 myoblasts induced to differentiate in vitro. Triplicate cultures were studied during cell proliferation (days -2 and -1), at cell cycle withdrawal (day 0) and during m...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-990 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C2C12 myoblasts induced to differentiate in vitro over a 12 day time series to identify novel genes involved in myogenic differentiation.
In this study, Affymetrix MG_U74Av2 and MG_U74Cv2 GeneChips were used to analyze gene expression over a 12 day time course in C2C12 myoblasts induced to differentiate in vitro. Triplicate cultures were studied during cell proliferation (days -2 and -1), at cell cycle withdrawal (day 0) and during m...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-989 | biostudies-arrayexpress
TranscriptomicsGene expression data from rapamycin resistant and sensitive cell lines
The mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation. Inhibitors of mTOR are being evaluated as anti-tumor agents. Given the emerging role of microRNAs (miRNAs) in tumorgenesis we hypothesized that miRNAs could play important roles in the response of tumors to mTOR i...
ORGANISM(S): Mus musculus 
2013-02-08 | E-GEOD-19885 | biostudies-arrayexpress
TranscriptomicsMicroRNAs mediate rapamycin resistance in a myogenic tumor cell line
The mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation. Inhibitors of mTOR are being evaluated as anti-tumor agents. Given the emerging role of microRNAs (miRNAs) in tumorgenesis we hypothesized that miRNAs could play important roles in the response of tumors to mTOR i...
ORGANISM(S): Mus musculus 
2013-02-08 | E-GEOD-19916 | biostudies-arrayexpress
Transcriptomicsdermatomyositis
muscle biopsies of normal and dermatomyositis patients
ORGANISM(S): Homo sapiens 
2007-08-03 | E-GEOD-1551 | biostudies-arrayexpress
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