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GenomicsThe GATA transcription factor GtaC regulates early developmental gene expression dynamics in Dictyostelium
In many developmental systems, morphogenesis is coupled with dramatic changes in spatiotemporal gene expression, often orchestrated by the coordinated action of transcription factors. Development of the social soil amoebae Dictyostelium discoideum proceeds through a sequence of morphological and tra...
ORGANISM(S): Dictyostelium discoideum 
2015-07-02 | E-GEOD-63151 | biostudies-arrayexpress
TranscriptomicsAllorecognition, via TgrB1 and TgrC1, mediates the transition from unicellularity to multicellularity in the social amoebae Dictyostelium discoideum
The social amoeba Dictyostelium discoideum integrates into a multicellular organism when individual starving cells aggregate and form a mound. The cells then integrate into defined tissues and develop into a fruiting body that consists of a stalk and spores. Aggregation is initially orchestrated by ...
ORGANISM(S): Dictyostelium discoideum 
2016-04-13 | E-GEOD-68063 | biostudies-arrayexpress
TranscriptomicsLeaps and lulls in the developmental transcriptome of Dictyostelium discoideum
Development of the soil amoeba Dictyostelium discoideum is triggered by starvation. When placed on a solid substrate, the starving solitary amoebae cease growth, communicate via extracellular cAMP, aggregate by tens of thousands and develop into fully integrated multicellular organisms. Early phases...
ORGANISM(S): Dictyostelium discoideum 
2015-04-21 | E-GEOD-61914 | biostudies-arrayexpress
TranscriptomicsBacterial discrimination by Dictyostelid amoebae reveals the complexity of ancient interspecies interactions
Transcriptional profiling of D. discoideum revealed sets of genes whose expression is enriched in amoebae interacting with different species of bacteria, including sets that appear specific to amoebae interacting with Gram(+), or with Gram(-) bacteria. In a genetic screen utilizing the growth of mut...
ORGANISM(S): Dictyostelium discoideum 
2013-05-20 | E-GEOD-46386 | biostudies-arrayexpress
TranscriptomicsTranscriptome comparison of oocytes obtained from in vitro culture and in vivo
The comparison of trancriptomes was part of the study by Pfender, Kuznetsov, Pasternak et al, titled: "Live imaging RNAi screen reveals genes essential for meiosis in mammalian oocytes". The goal was to check if the oocytes cultured in vitro in follicles (for RNAi studies) correspond to re...
ORGANISM(S): Mus musculus 
2015-07-06 | E-GEOD-68150 | biostudies-arrayexpress
Transcriptomicsabc transporters in Dictyostelium discoideum development
ATP-binding cassette (ABC) transporters can translocate a broad spectrum of molecules across the cell membrane including physiological cargo and toxins. ABC transporters are known for the role they play in resistance towards anticancer agents in chemotherapy of cancer patients. There are 68 ABC tran...
ORGANISM(S): Dictyostelium discoideum AX4 
2013-06-14 | E-GEOD-45555 | biostudies-arrayexpress
TranscriptomicsNucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer
Biological oscillations are observed at many levels of cellular organization. In the social amoebae Dictyostelium discoideum, starvation-triggered multicellular development is organized by periodic cAMP waves, which provide both chemoattractant gradients and developmental signals. We report that Gta...
ORGANISM(S): Dictyostelium discoideum 
2014-04-15 | E-GEOD-54866 | biostudies-arrayexpress
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