Sort   by:  
 Page size 
ProteomicsTAK285 induced degradation – selectivity profiling in NALM-6 cells
The hit compound TAK285 was subjected to full proteome profiling by TMTpro 6-plex to assess its degradation selectivity in NALM-6 cells. TAK285 induced the degradation of the kinase BLK. The compound was further mechanistically dissected as reported with orthogonal assays such as FACS-based CRISPR/C...
ORGANISM(S): Homo sapiens (Human) 
2025-09-04 | PXD059599 | Pride
Kinase inhibitors Tmt 
ProteomicsSelectivity profiling of inhibitor treated human cells via full proteome profiling
Three selective hit compounds from an arrayed kinome abundance screen (98 kinases vs 1570 kinase inhibitors) were subjected to full proteome profiling by TMTpro 18-plex to assess their degradation selectivity in K562 cells. Src inhibitor 3 showed the most significant downregulation of the target kin...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD053130 | Pride
K562 Kinase inhibitors Monovalent degrader Tmt 
TranscriptomicsCopy number data from GIST with KIT mutation
In addition to KIT and PDGFRA mutations, sequential accumulation of other genetic events is involved in the development and progression of gastrointestinal stromal tumors (GISTs). Until recently, the significance of these other alterations has not been thoroughly investigated. The combination of gen...
ORGANISM(S): Homo sapiens 
2010-08-27 | E-GEOD-20709 | biostudies-arrayexpress
ProteomicsProbing kinase proximity interactome modulation upon drug treatment by miniTurboID proximity labelling
In a systematic effort to profile kinase inhibitors, which also act as degraders, we identified multiple hit compounds. These were subjected to detailed mechanism of action elucidation including analysis of the perturbed interactome and its effect on degradation. For our first example, LYN, Src inhi...
ORGANISM(S): Homo sapiens (Human) 
2025-09-04 | PXD062184 | Pride
Kinase inhibitors Tmt 
UnknownVariation in Mammographic Breast Density Assessments Among Radiologists in Clinical Practice: A Multicenter Observational Study.
Not available
S-EPMC5050130 | biostudies-literature
UnknownBeyond species means - the intraspecific contribution to global wood density variation.
Not available
S-EPMC12917463 | biostudies-literature
UnknownOutcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study.
Not available
S-EPMC8634634 | biostudies-literature
UnknownExtended pharmacological thromboprophylaxis and clinically relevant venous thromboembolism after major abdominal and pelvic surgery: international, prospective, propensity score-weighted cohort study.
Not available
S-EPMC11894929 | biostudies-literature
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
Sort   by:  
 Page size