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The epidermal-specific ablation of Rb gene leads to increased proliferation, aberrant differentiation, and the disengagement of these processes in vivo and in vitro. These differences in phenotype are more severe with the loss of p107, demonstrating the functional compensation between pRb and p107. ...
ORGANISM(S): Mus musculus 
Four L. sativus accessions, exhibiting varying levels of resistance to E. pisi (resistant, partially resistant, partially susceptible, and susceptible), were analysed using dual RNA-seq. Leaflets from each plant were sampled at 0 (non-inoculated), 6, 12, 24, 48, and 72 hours after inoculation. Forty...
ORGANISM(S): Lathyrus sativus 
A permantly active form of the oncogene Akt was expressed in the keratinocytes of the basal proliferative layer of the epidermis. Stem cells of the hair follicle expressing the cell surface marker CD34 were isolated. RNA form the CD34(+) and CD34(-) keratinocytes was extracted and and hybridized to ...
ORGANISM(S): Mus musculus 
Seven closely related species from Hologalegina and Phaseoloid clades were selected: Lathyrus sativus, Pisum sativum (Lathyrus oleraceus), Lens culinaris, Cicer arietinum, Medicago truncatula, Glycine max, and Phaseolus vulgaris, to assess tissue-specific expression in non-inoculated conditions. Pla...
ORGANISM(S): Lathyrus sativus 
Extracellular vesicle (EV) proteomics holds great promise for non-invasive cancer biomarker discovery. This study presents the first comprehensive proteomic characterization of EVs from tissue, plasma, and urine, focusing on bladder cancer BlCa. EVs were isolated via ultracentrifugation, and their c...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD062618 | Pride
Background: There is an urgent need for the development of innovative diagnostic and therapeutic strategies in bladder cancer (BlCa) management, due to its significant incidence, mortality and morbidity. Extracellular vesicles (EVs) represent highly promising candidates as biomarkers, as their cargo...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD071837 | Pride
The epidermal specific ablation of Trp53 gene leads to the spontaneous development of aggressive tumors in mice through a process that is accelerated by the simultaneous ablation of Rb gene. Since alterations of p53-dependent pathway are common hallmarks of aggressive, poor prognostic human cancers,...
ORGANISM(S): Mus musculus 
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