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MetabolomicsRepurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they neg...
2021-10-06 | MTBLS2166 | MetaboLights
GenomicsPTIP promotes chromatin changes critical for immunoglobulin class switch recombination
Programmed genetic rearrangements in lymphocytes require transcription at antigen receptor genes to promote accessibility for initiating double-strand break (DSB) formation critical for DNA recombination and repair. Here we show that activated B cells deficient in the PTIP component of the MLL3 (mix...
ORGANISM(S): Mus musculus 
2010-08-25 | E-GEOD-20852 | biostudies-arrayexpress
MetabolomicsSubcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means t...
2020-12-07 | MTBLS959 | MetaboLights
TranscriptomicsTranscription profiling by array of human peripheral blood gamma-delta T cells stimulated with HMB-PP or OKT-3
Here we compare the transcriptional profile of HMB-PP-stimulated versus OKT-3 stimulated human peripheral blood gamma-delta T cells. We show that HMB-PP faithfully reproduces the transcriptional events associated with bona fide activation through the T cell receptor (TCR).
ORGANISM(S): Homo sapiens 
2008-09-01 | E-MEXP-1601 | biostudies-arrayexpress
TranscriptomicsGenome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays
This series represents 52 tissues hybridized across 5 different chip patterns. Probes were placed at every exon-exon junction in each transcript. Keywords = junction alternate splicing oligonucleotide Keywords: parallel sample. This dataset is part of the TransQST collection.
ORGANISM(S): Homo sapiens 
2003-12-19 | E-GEOD-740 | biostudies-arrayexpress
UnknownSynthetic Antigens Derived from Plasmodium falciparum Sporozoite, Liver, and Blood Stages: Naturally Acquired Immune Response and Human Leukocyte Antigen Associations in Individuals Living in a Brazilian Endemic Area.
Not available
S-EPMC5817778 | biostudies-literature
UnknownCompassion Fatigue and Burnout Among Health Care Professionals: Protocol for a Scoping Review.
Not available
S-EPMC12329385 | biostudies-literature
UnknownPTIP promotes chromatin changes critical for immunoglobulin class switch recombination.
Not available
S-EPMC3008398 | biostudies-literature
UnknownEvaluation of the genetic polymorphism of Plasmodium falciparum P126 protein (SERA or SERP) and its influence on naturally acquired specific antibody responses in malaria-infected individuals living in the Brazilian Amazon.
Not available
S-EPMC2515332 | biostudies-literature
TranscriptomicsPausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation: Expression data
Metazoan transcription is controlled through either coordinated recruitment of transcription machinery to the gene promoter, or subsequently, through regulated pausing of RNA polymerase II (Pol II) in early elongation. We report that a key difference between genes that use these distinct regulatory ...
ORGANISM(S): Drosophila melanogaster 
2010-10-18 | E-GEOD-24133 | biostudies-arrayexpress
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