Sort   by:  
 Page size 
TranscriptomicsThe TCR activation acts as a tumor suppressor mechanism in T-ALL
Developmental checkpoints in stem/progenitor cells are critical to the determination, commitment and differentiation into distinct lineages. Cancer cells often retain expression of lineage-specific checkpoint proteins, but their potential impact in cancer remains elusive. T lymphocytes mature in the...
ORGANISM(S): Homo sapiens 
2016-08-20 | E-GEOD-65496 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human peripheral blood gamma-delta T cells stimulated with HMB-PP or OKT-3
Here we compare the transcriptional profile of HMB-PP-stimulated versus OKT-3 stimulated human peripheral blood gamma-delta T cells. We show that HMB-PP faithfully reproduces the transcriptional events associated with bona fide activation through the T cell receptor (TCR).
ORGANISM(S): Homo sapiens 
2008-09-01 | E-MEXP-1601 | biostudies-arrayexpress
TranscriptomicsGene expression data of diagnostic childhood T-ALL samples and human thymocytes
Lymphotoxin-mediated activation of the lymphotoxin-β receptor (LTβR) has been implicated in several physiological and pathological processes, including lymphoid organ development, T-cell maturation, and solid and hematopoietic malignancies. Its role in T-cell acute lymphoblastic leukemia (T-ALL) o...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-66638 | biostudies-arrayexpress
TranscriptomicsPeripheral tissue instruction is the primary determinant of CD8+ T cell pathogenicity: transcription profiling by array of donor CD8+ effector T cells isolated from the secondary lymphoid organs, blood and GVHD-target organs at D+6 post-transplant (F>M model)
This study reports the evolution of the donor CD8 effector T cell transcriptomes at multiple sites and time points within the same host following allo-SCT. Donor derived CD8+ T cells were flow sorted from multiple organs in mice developing GVHD in two clinically relevant murine models of H-2b MHC-ma...
ORGANISM(S): Mus musculus 
2018-03-28 | E-MTAB-5379 | biostudies-arrayexpress
TranscriptomicsPeripheral tissue instruction is the primary determinant of CD8+ T cell pathogenicity: transcription profiling by array of donor CD8+ effector T cells isolated from the secondary lymphoid organs, blood and GVHD-target organs at D+6 post-transplant (B6>129 model)
This study reports the evolution of the donor CD8 effector T cell transcriptomes at multiple sites and time points within the same host following allo-SCT. Donor derived CD8+ T cells were flow sorted from multiple organs in mice developing GVHD in two clinically relevant murine models of H-2b MHC-ma...
ORGANISM(S): Mus musculus 
2017-01-16 | E-MTAB-5378 | biostudies-arrayexpress
TranscriptomicsPeripheral tissue instruction is the primary determinant of CD8+ T cell pathogenicity: transcription profiling by array of donor CD8+ effector T cells isolated from the secondary lymphoid organs, blood and GVHD-target organs at D+7 post-transplant (FTY720)
This study reports the evolution of the donor CD8 effector T cell transcriptomes at multiple sites and time points within the same host following allo-SCT. Donor derived CD8+ T cells were flow sorted from multiple organs in mice developing GVHD in two clinically relevant murine models of H-2b MHC-ma...
ORGANISM(S): Mus musculus 
2018-03-28 | E-MTAB-5380 | biostudies-arrayexpress
ProteomicsDetermining changes in the oxidized proteome of human CD8+ T cells with enhancing proteasome activity
Chronic T cell receptor (TCR) stimulation, combined with adverse conditions in the tumor microenvironment (TME) such as hypoxia and nutrient deprivation, frequently results in T cell exhaustion. Exhausted T cells (TEX) experience oxidative stress, which causes an accumulation of oxidized proteins wi...
ORGANISM(S): Homo sapiens (Human) 
2026-03-12 | PXD070152 | Pride
Exhausted t cells (tex) Oxidative stress Proteasome 
ProteomicsA dual role for FADD in human T-cell lymphoblastic neo-plasms
In this study, we set out to get insight into the clinical implications of FADD expres-sion in T-cell lymphoblastic neoplasms, and to explore the landscape of deregulated cell signaling events in human T-cell lymphoblastic neoplasms, taking FADD expression as the defining variable.
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037858 | Pride
Dia T-lbl Fadd 
TranscriptomicsTranscription profiling of murine leukemic T cells from Ikaros-deficient mice and wild type mice to identify critical gene expression events during T-cell leukemogenesis.
The experiment was to compare leukemic T cells from thymic lymphomas from homozygote mice for the IkL/L hypomorphic mutation and non-transformed thymocytes, either of WT or IkL/L genotype. The aim was to identify a gene expression signature specific to the IkL/L tumors.
ORGANISM(S): Mus musculus 
2007-09-04 | E-GEOD-2501 | biostudies-arrayexpress
TranscriptomicsPeripheral tissue instruction is the primary determinant of CD8+ T cell pathogenicity: transcription profiling by RNA-seq of CD8+ effector T cells isolated from the blood and skin of HSCT patients developing acute pattern GVHD.
To determine whether murine GVHD associated tissue-specific signatures of donor CD8+ effector T cells are conserved at the same locations in humans developing GVHD, we compared the transcriptional profile of CD8+ T cells obtained simultaneously from the blood and skin of 5 patients developing acute ...
ORGANISM(S): Homo sapiens 
2018-03-28 | E-MTAB-5381 | biostudies-arrayexpress
Sort   by:  
 Page size