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ProteomicsHIC1 interacts with FOXP3 multi protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function
Transcriptional repressor, hypermethylated in cancer 1 (HIC1) is an important contributor to regulatory T (Treg) cell development and function. To investigate the mechanism by which it regulates Treg cell development, we systematically characterized the HIC1 interactome by affinity-purification mass...
ORGANISM(S): Homo Sapiens 
PXD038532 | panorama
MetabolomicsCirculating Metabolites in Progression to Islet Autoimmunity and Type 1 Diabetes

AIMS/HYPOTHESIS: Metabolic dysregulation may precede the onset of type 1 diabetes. However, these metabolic disturbances and their specific role in disease initiation remain poorly understood. In this study, we examined whether children who progress to type 1 diabetes have a cir...

2022-01-19 | MTBLS802 | MetaboLights
TranscriptomicsTranscription profiling of Basmati T-DNA insertional mutant lines
The aim of this study was to look for the changes at the transcriptome level caused by the same T-DNA cassette in three mutants of Basmati 370 with different phenotypes. The comparative analysis of differentially expressed genes was conducted individually and collectively for all three mutants. RNA ...
ORGANISM(S): Oryza sativa Indica Group 
2013-12-31 | E-GEOD-31248 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type Basmati 370 and its T-DNA insertional mutant OsAPC6.
The aim of this study was to look for the changes at the transcriptome level caused by the insertion of a T-DNA in mutant of Basmati 370 with dwarf phenotype. The comparative analysis of differentially expressed genes was conducted individually and collectively for both. RNA from wild type Basmati ...
ORGANISM(S): Oryza sativa Indica Group 
2013-12-31 | E-GEOD-31200 | biostudies-arrayexpress
ProteomicsCIP2A negatively regulates Th17 differentiation
Interleukin 17 (IL-17) producing T helper 17 (Th17) cells are critical drivers of pathogenesis in a variety of autoimmune and inflammatory diseases. Strategies to mitigate excessive Th17 response thus remain an attractive target for immunotherapies. Here we report that Cancerous Inhibitor of Protein...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD010612 | Pride
Th17 cell differentiation Stat3 phosphorylation 
MetabolomicsDynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes: Type 1 Diabetes Prediction and Prevention Study (DIPP)
Type 1 diabetes (T1D) is one of the most prevalent autoimmune diseases among children in Western countries. Earlier metabolomics studies suggest that T1D is preceded by dysregulation of lipid metabolism. Here we used a lipidomics approach to analyze molecular lipids in a prospective series of 428 pl...
2018-07-16 | MTBLS620 | MetaboLights
UnknownBeyond FOXP3: a 20-year journey unravelling human regulatory T-cell heterogeneity.
Not available
S-EPMC10811018 | biostudies-literature
UnknownComputational approach for identifying immunogenic epitopes and optimizing peptide vaccine through in-silico cloning against Mycoplasma genitalium.
Not available
S-EPMC11002066 | biostudies-literature
UnknownTranscriptomics analysis unveils the complex interplay between diabetes and hypertension in regulating renal cell carcinoma pathway followed by pancreatic metastasis.
Not available
S-EPMC12704389 | biostudies-literature
UnknownStroke penumbra defined by an MRI-based oxygen challenge technique: 1. Validation using [14C]2-deoxyglucose autoradiography.
Not available
S-EPMC3154682 | biostudies-literature
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