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UnknownLoss of <i>Cdkn1a</i> protects against MASLD alone or with alcohol intake by preserving lipid homeostasis.

Background & aims

Expression of P21, encoded by the CDKN1A gene, has been associated with fibrosis progression in steatotic liver disease (SLD); however, the underlying mechanisms remain unknown. In the present study, we investigated the function of CDKN1A in SLD.

Methods

CD...
S-EPMC11629569 | biostudies-literature
UnknownSelective chemical recycling of polyhydroxybutyrate into high-value hydroxy acid using the taurine organocatalyst.
Polyhydroxyalkanoates (PHAs) are receiving significant attention due to their biobased origin, biodegradability, and excellent barrier properties. However, their high cost compared to traditional plastics necessitates the development of recycling technologies to retain their value post-use. Despite ...
S-EPMC12264751 | biostudies-literature
UnknownFunctional Status of Patients over 65 Years Old Intervened on for a Hip Fracture One Year after the Operation.

Objectives

Evaluation of the functional status one year after a hip fracture surgery and the influence of sarcopenia and other clinical factors at the time of admission.

Method

Prospective observational study with 135 patients over 65 years of age. Functional status of basic (modified...
S-EPMC10217831 | biostudies-literature
UnknownVaginal neutrophil infiltration is contingent on ovarian cycle phase and independent of pathogen infection.
The mucosa of the female reproductive tract must reconcile the presence of commensal microbiota and the transit of exogenous spermatozoa with the elimination of sexually transmitted pathogens. In the vagina, neutrophils are the principal cellular arm of innate immunity and constitute the first line ...
S-EPMC9771706 | biostudies-literature
UnknownDisease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: A real-world nationwide analysis.

Background

To evaluate gender differences in disease activity and health status (HS) in patients with radiographic axial spondyloarthritis (r-axSpA)/ankylosing spondylitis (AS).

Methods

Ancillary analysis of the MIDAS study, an observational, non-interventional, cross-sectional and re...
S-EPMC9811117 | biostudies-literature
UnknownSelf-sufficient asymmetric reduction of β-ketoesters catalysed by a novel and robust thermophilic alcohol dehydrogenase co-immobilised with NADH.
β-Hydroxyesters are essential building blocks utilised by the pharmaceutical and food industries in the synthesis of functional products. Beyond the conventional production methods based on chemical catalysis or whole-cell synthesis, the asymmetric reduction of β-ketoesters with cell-free enzymes is...
S-EPMC8111925 | biostudies-literature
UnknownRegulation of Fn14 Receptor and NF-κB Underlies Inflammation in Meniere's Disease.
Meniere's disease (MD) is a rare disorder characterized by episodic vertigo, sensorineural hearing loss, tinnitus, and aural fullness. It is associated with a fluid imbalance between the secretion of endolymph in the cochlear duct and its reabsorption into the subarachnoid space, leading to an accum...
S-EPMC5733484 | biostudies-literature
UnknownCytokines and Lymphoid Populations as Potential Biomarkers in Locally and Borderline Pancreatic Adenocarcinoma.
Despite its relative low incidence, PDAC is one of the most aggressive and lethal types of cancer, being currently the seventh leading cause of cancer death worldwide, with a 5-year survival rate of 10.8%. Taking into consideration the necessity to improve the prognosis of these patients, this resea...
S-EPMC9739487 | biostudies-literature
UnknownThe Sabatier principle governs the performance of self-sufficient heterogeneous biocatalysts for redox biotransformations.
Self-sufficient heterogeneous biocatalysts (ssHBs), in which enzymes and cofactors are coimmobilized on the same support, provide in situ cofactor regeneration and reduce operating costs. However, the underlying mechanisms remain poorly understood. Here, we present a theoretical model for ssH...
S-EPMC12267118 | biostudies-literature
UnknownPhenotype-Specific Mitochondrial Responses to Mediterranean Diet and Exercise in Elderly Obesity.
Background/Objectives: While excessive body fat is commonly linked to metabolic disorders (metabolically unhealthy obesity, MUO), a subset of individuals remain metabolic healthy despite obesity (metabolically healthy obesity, MHO). This work aims to determine how these phenotypes influence r...
S-EPMC12899043 | biostudies-literature
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