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MetabolomicsLipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy
As a consequence of impaired glucose or fatty acid metabolism, bioenergetic stress in skeletal muscles may trigger myopathy and rhabdomyolysis. Genetic mutations causing loss of function of the LPIN1 gene frequently lead to severe rhabdomyolysis bouts in children, though the metabolic alterations an...
2019-01-07 | MTBLS750 | MetaboLights
ProteomicsObscurin and Obsl1 functions for “Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism.”
“Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism.”
ORGANISM(S): Mus musculus (Mouse) 
2019-05-20 | PXD013008 | Pride
Obscurin Obsl1 Sarcoplasmic reticulum organization Muscle metabolism Sarcolemmal integrity 
GenomicsZnhit1-deficiency caused sarcoplasmic reticulum originated vacuolar cardiomyopathy
Znhit1-deficiency caused sarcoplasmic reticulum originated vacuolar cardiomyopathy
PRJNA799336 | ENA
ProteomicsAn Investigation of the Altered Textural Property in Woody Breast Myopathy Using an Integrative Omics Approach
The functionality/integrity of sarcoplasmic reticulum was compared between normal vs. myopathic woody breast tissues in Gallus gallus. Shotgun MS profiling of protein expression revealed an upregulation of calcium transport proteins and a downregulation of proteins responsible for calcium release. ...
ORGANISM(S): Gallus gallus (Chicken) 
2022-05-19 | PXD031445 | Pride
Woody breast myopathy in gallus gallus Sarcoplasmic reticulum Dda shotgun profiling on fusion ms Calcium signalling Maxquant 
GenomicsDIAPH1-MFN2 interaction regulates mitochondria-sarcoplasmic reticulum contact and modulates ischemic/hypoxic stress
DIAPH1-MFN2 interaction regulates mitochondria-sarcoplasmic reticulum contact and modulates ischemic/hypoxic stress
PRJNA884121 | ENA
UnknownAltered sarcoplasmic reticulum calcium cycling--targets for heart failure therapy.
Not available
S-EPMC3651893 | biostudies-literature
ProteomicsA function-based determination of the cardiac endoplasmic and sarcoplasmic reticulum proteome
Cardiac sarcoplasmic reticulum (SR) plays a central role in cellular Ca homeostasis, as does endoplasmic reticulum (ER) in the nonmuscle cell. The importance of SR Ca-handling function has led to detailed understanding of Ca-release and re-uptake protein complexes, but relatively little information...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2024-01-26 | PXD022455 | Pride
Proteomics Serca Cardiac sarcoplasmic reticulum Cardiac muscle Ryanodine receptor 
UnknownPurification of sarcoplasmic reticulum vesicles from horse gluteal muscle.
Not available
S-EPMC7745508 | biostudies-literature
TranscriptomicsExpression data from from the E9.25 hearts of mouse embryos
Congenital heart defects (CHDs) occur in 0.5–1% of live births, yet the underlying genetic etiology remains mostly unknown. Recently, a new source of myocardial cells, namely the second heart field (SHF), was discovered in the splanchnic mesoderm. Abnormal development of the SHF leads to a spectrum ...
ORGANISM(S): Mus musculus 
2011-03-26 | E-GEOD-28186 | biostudies-arrayexpress
UnknownSize Matters: Ryanodine Receptor Cluster Size Affects Arrhythmogenic Sarcoplasmic Reticulum Calcium Release.
Not available
S-EPMC6064922 | biostudies-literature
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