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ProteomicsNeprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides
Muscle contraction depends on strictly controlled Ca2+ transients within myocytes. A major player maintaining these transients is the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase, SERCA. Activity of SERCA is regulated by binding of micropeptides and impaired expression or function of these peptide...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-06-01 | PXD027738 | Pride
Neprilysin Calcium homeostasis Metallopeptidase Micropeptides Serca Heart physiology Drosophila melanogaster 
TranscriptomicsTranscription profiling of human non-malignant fallopian tube epithelium and high grade serous carcinoma.
The purpose of this study was to identify molecular alterations potentially involved in predisposition to adnexal serous carcinoma (SerCa) in the non-malignant fallopian tube epithelium (FTE) of BRCA1/2-mutation carriers, given recent evidence implicating the distal FTE as a common source for SerC...
ORGANISM(S): Homo sapiens 
2008-06-18 | E-GEOD-10971 | biostudies-arrayexpress
ProteomicsA function-based determination of the cardiac endoplasmic and sarcoplasmic reticulum proteome
Cardiac sarcoplasmic reticulum (SR) plays a central role in cellular Ca homeostasis, as does endoplasmic reticulum (ER) in the nonmuscle cell. The importance of SR Ca-handling function has led to detailed understanding of Ca-release and re-uptake protein complexes, but relatively little information...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2024-01-26 | PXD022455 | Pride
Proteomics Serca Cardiac sarcoplasmic reticulum Cardiac muscle Ryanodine receptor 
UnknownA novel SERCA inhibitor demonstrates synergy with classic SERCA inhibitors and targets multidrug-resistant AML.
Not available
S-EPMC3946399 | biostudies-literature
UnknownCa2+-dependent redox modulation of SERCA 2b by ERp57.
Not available
S-EPMC2171954 | biostudies-literature
UnknownNitroxyl activates SERCA in cardiac myocytes via glutathiolation of cysteine 674.
Not available
S-EPMC3046805 | biostudies-literature
UnknownTargeting oncogenic Notch signaling with SERCA inhibitors.
Not available
S-EPMC7789735 | biostudies-literature
UnknownThe Phospholamban Pentamer Alters Function of the Sarcoplasmic Reticulum Calcium Pump SERCA.
Not available
S-EPMC6383005 | biostudies-literature
UnknownRedistribution of SERCA calcium pump conformers during intracellular calcium signaling.
Not available
S-EPMC6052202 | biostudies-literature
UnknownTime-resolved FRET reveals the structural mechanism of SERCA-PLB regulation.
Not available
S-EPMC4054823 | biostudies-literature
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